Fig. 5

Inhibition of radiation-enhancement of lung metastases with chloroquine. a Quantification of circulating tumor cells in blood samples of sham and irradiated mice. b Optical imaging of lung metastases. ****P < 0.0001. c Quantification of the number of lung metastases. *P < 0.05, **P < 0.01. Sham: Non-irradiated animals with tumor implantation on both sides. Irradiation: Pre-irradiation of the right mammary gland following by tumors implantation on both sides. d Quantification of the diameter of lung metastases from optical imaging results. No significant difference was observed for sham or irradiated mice, as for chloroquine treatment. Error bars indicate standard error of the mean (SEM) for n = 4 to 15 animals for each group