Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival

Table 4 Genomic deletions and gains shared by 2 or more germline mutated tumors

					BRCA2 mutated tumors				BRCA1 mutated tumors
					Mutation 1		Mutation 2		Mutation 3	Mutation 4
Chr region	Start	Stop	Size bp	Genes	T50	T5	T51	T44	T49	T24	T25
1q41	212228277	212570219	341942	PROX1, SMYD2		Loss		Loss
2p25.1	11198066	11682912	484846	PQLC3, ROCK2, E2F6, GREB1				Gain		Gain
2q33.1	197759971	197921182	161211	ANKRD44				Loss		Loss
2q33.2	203984291	204102868	118577	ABI2, RAPH1	Loss	Loss				Loss
4q32.3-4q33	167949877	170912917	2963040	SPOCK3, ANXA10, DDX60, PALLD, CBR4, SH3RF1, NEK1, CLCN3	Loss	Loss
4q34.1-4q34.2	175832063	176792165	960102	GLRA3, ADAM29, GMP6A	Loss					Loss
7p13	43308108	44125072	816964	HECW1, STK17A, BLVRA, MRPS24, URG4, UDE2D4, DBNL, PGAM2, POLM, AEBP1, POLD2		Loss		Loss
11q12.1	58254147	58647789	393642	GLYAT, GLYATL2, GLYATL1	Loss	Loss
17q21.2	38450905	38521318	70413	BRCA1				Loss	Loss	Loss
17q23.2	57344164	57454012	109848	INTS2, MED13		Loss			Loss
19q13.11	40168316	40221937	53621	GRAMD1A, SCN1B	Loss				Loss
20q13.12	44813919	45159168	345249	EYA2	Loss			Loss	Loss

In bold are highlighted cancer associated genes found in genomic losses and gains present only in BRCA1 and BRCA2 tumors

ISSN: 1471-2407