Prognostic factors | Overall survival | Disease free survival | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Unadjusteda | Full modelb | Backwards variable selectionc | Unadjusteda | Full modelb | Backwards variable selectionc | ||||||||
HR (95 % CI) | p * | HR (95 % CI) | p* | HR (95 % CI) | p* | HR (95 % CI) | p* | HR (95 % CI) | p * | HR (95 % CI) | p* | ||
Cancer resection | Elective | Reference | 0.045 | Reference | 0.629 | – | – | Reference | 0.043 | Reference | 0.877 | – | – |
Urgent | 1.35 (1.02–1.78) | 1.08 (0.79–1.48) | – | – | 1.33 (1.02–1.74) | 1.02 (0.76–1.38) | – | – | |||||
Age | years | 1.04 (1.03–1.05) | <0.001 | 1.05 (1.04–1.06) | <0.001 | 1.05 (1.04–1.06) | <0.001 | 1.03 (1.03–1.04) | <0.001 | 1.04 (1.03–1.05) | <0.001 | 1.04 (1.03–1.05) | <0.001 |
Sex | m | Reference | 0.973 | Reference | 0.850 | – | – | Reference | 0.478 | Reference | 0.381 | – | – |
w | 1.00 (0.84–1.20) | 0.98 (0.81–1.19) | – | – | 0.94 (0.79–1.12) | 0.92 (0.76–1.11) | – | – | |||||
Tumor localisation | Cecum | Reference | 0.004 | Reference | 0.002 | Reference | 0.003 | Reference | 0.018 | Reference | 0.026 | Reference | 0.031 |
Asc. colon | 0.72 (0.53–0.96) | 0.60 (0.44–0.82) | 0.62 (0.46–0.83) | 0.76 (0.57–1.02) | 0.67 (0.49–0.91) | 0.68 (0.50–0.91) | |||||||
Transv. colon | 0.81 (0.53–1.23) | 0.62 (0.40–0.97) | 0.63 (0.41–0.97) | 0.78 (0.51–1.18) | 0.62 (0.40–0.95) | 0.63 (0.41–0.96) | |||||||
Desc. olon | 0.87 (0.62–1.22) | 0.90 (0.63–1.28) | 0.90 (0.64–1.27) | 0.94 (0.68–1.31) | 0.99 (0.70–1.39) | 1.03 (0.74–1.45) | |||||||
Sigm. colon | 0.73 (0.56–0.95) | 0.66 (0.50–0.88) | 0.68 (0.51–0.89) | 0.80 (0.62–1.04) | 0.79 (0.60–1.05) | 0.83 (0.63–1.08) | |||||||
Rectum | 0.56 (0.42–0.74) | 0.57 (0.42–0.79) | 0.58 (0.43–0.78) | 0.62 (0.47–0.81) | 0.70 (0.51–0.95) | 0.74 (0.56–0.99) | |||||||
Perforation | No | Reference | 0.525 | Reference | 0.492 | – | – | Reference | 0.684 | Reference | 0.704 | – | – |
Yes | 1.10 (0.82–1.49) | 1.13 (0.80–1.58) | – | – | 1.06 (0.79–1.42) | 1.07 (0.77–1.48) | – | – | |||||
Protec. colostomy | No | Reference | 0.929 | Reference | 0.530 | – | – | Reference | 0.987 | Reference | 0.783 | – | – |
Yes | 1.01 (0.77–1.33) | 1.10 (0.81–1.50) | – | – | 1.00 (0.77–1.31) | 1.04 (0.77–1.41) | – | – | |||||
Resection status | R0 | Reference | <0.001 | Reference | 0.001 | Reference | <0.001 | Reference | <0.001 | Reference | 0.004 | Reference | 0.003 |
R1/2 | 3.21 (2.16–4.75) | 2.22 (1.45–3.38) | 2.30 (1.52–3.49) | 3.07 (2.08–4.55) | 1.97 (1.29–3.02) | 1.97 (1.30–3.00) | |||||||
UICC Stage | I | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 | Reference | <0.001 |
II | 1.28 (0.97–1.69) | 1.21 (0.89–1.64) | 1.25 (0.93–1.67) | 1.41 (1.08–1.85) | 1.39 (1.03–1.87) | 1.37 (1.03–1.82) | |||||||
III | 1.67 (1.27–2.19) | 1.67 (1.22–2.29) | 1.74 (1.29–2.36) | 1.80 (1.38–2.34) | 1.79 (1.31–2.43) | 1.75 (1.30–2.36) | |||||||
IV | 4.02 (3.02–5.35) | 4.89 (3.45–6.94) | 5.10 (3.64–7.14) | 4.83 (3.65–6.40) | 5.64 (3.99–7.97) | 5.58 (4.00–7.79) | |||||||
Tumor diameter | mm | 1.00 (1.00–1.01) | 0.071 | 1.00 (1.00–1.01) | 0.730 | – | – | 1.00 (1.00–1.01) | 0.043 | 1.00 (1.00–1.01) | 0.829 | – | – |
Lymph node yield | <12 | Reference | 0.662 | Reference | 0.006 | Reference | 0.007 | Reference | 0.662 | Reference | 0.173 | – | – |
12+ | 0.95 (0.77–1.18) | 0.72 (0.57–0.91) | 0.73 (0.58–0.91) | 1.05 (0.85–1.29) | 0.85 (0.68–1.07) | – | – | ||||||
Tumor grading | G1 | Reference | 0.012 | Reference | 0.367 | – | – | Reference | 0.001 | Reference | 0.009 | Reference | 0.007 |
G2 | 1.09 (0.65–1.82) | 1.23 (0.72–2.09) | – | – | 1.07 (0.65–1.77) | 1.21 (0.72–2.03) | 1.20 (0.72–2.00) | ||||||
G3 | 1.58 (0.92–2.71) | 1.41 (0.80–2.47) | – | – | 1.66 (0.98–2.81) | 1.45 (0.84–2.50) | 1.42 (0.83–2.45) | ||||||
GX | 1.33 (0.69–2.57) | 1.59 (0.81–3.14) | – | – | 1.57 (0.84–2.95) | 2.44 (1.27–4.68) | 2.49 (1.31–4.73) | ||||||
Adjuvant chemo. | No | Reference | 0.679 | Reference | 0.042 | Reference | 0.027 | Reference | 0.501 | Reference | 0.142 | Reference | 0.142 |
Yes | 0.96 (0.79–1.17) | 0.77 (0.60–0.99) | 0.76 (0.60–0.97) | 1.07 (0.88–1.29) | 0.84 (0.66–1.06) | 0.84 (0.66–1.06) |