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Table 5 Most important treatment goals

From: Myeloproliferative neoplasms (MPNs) have a significant impact on patients’ overall health and productivity: the MPN Landmark survey

  

Symptom Quartile

Prognostic Risk

Treatment Goal,a n (%)

All Respondents

Q4

Q1

High

Low

MF

n = 207

n = 73

n = 43

n = 63

n = 9

 Slow/delay progression of condition

86 (42)

27 (37)

18 (42)

28 (44)

6 (67)

 Better QoL

43 (21)

26 (36)

2 (5)

16 (25)

0

 Healthy blood counts

23 (11)

6 (8)

10 (23)

5 (8)

1 (11)

 Symptom improvement

14 (7)

5 (7)

1 (2)

1 (2)

1 (11)

 Reduction in spleen size

13 (6)

2 (3)

5 (12)

3 (5)

0

 Reduce blood transfusions

12 (6)

4 (6)

2 (5)

6 (10)

0

PV

n = 380

n = 98

n = 88

n = 101

n = 26

 Slow/delay progression of condition

96 (25)

23 (24)

21 (24)

20 (20)

7 (27)

 Prevention of vascular/thrombotic events

92 (24)

17 (17)

16 (18)

25 (25)

5 (19)

 Healthy blood counts

68 (18)

10 (10)

27 (31)

22 (22)

3 (12)

 Better QoL

45 (12)

19 (19)

5 (6)

11 (11)

4 (15)

 Symptom improvement

33 (9)

21 (21)

1 (1)

6 (6)

2 (8)

 Hematocrit levels <45 %

22 (6)

4 (4)

9 (10)

9 (9)

1 (4)

ET

n = 226

n = 42

n = 71

n = 35

n = 46

 Prevention of vascular/thrombotic events

78 (35)

9 (21)

28 (39)

12 (34)

15 (33)

 Slow/delay progression of condition

48 (21)

8 (19)

16 (23)

5 (14)

14 (30)

 Healthy blood counts

39 (17)

5 (12)

18 (25)

5 (14)

4 (9)

 Better QoL

31 (14)

14 (33)

2 (3)

3 (9)

9 (20)

 Symptom improvement

21 (9)

3 (7)

3 (4)

6 (17)

2 (4)

  1. ET = essential thrombocythemia; MF = myelofibrosis; PV = polycythemia vera; QoL = quality of life
  2. aMost important treatment goal, other than a cure, reported by ≥5 % of respondents in each MPN group