Table 3 Patients and tumor characteristics according to the intratumoral OCT1 mRNA expression

Gender

 male

14

40

 female

1

5

1.000

(Fisher’s exact test)

Mean age

 years (standard deviation)

65.022 (7.190)

64.658 (11.667)

0.910

(unpaired t test)

Underlying liver disease

 alcohol

2

14

 HBV

3

8

 HCV

4

8

 steatosis or NASH

0

5

 others

5

6

 unknown

1

4

0.224

(Fisher’s exact test)

Prior HCC treatment

 yes

6

29

 no

9

16

0.133

(Fisher’s exact test)

Tumor grading

 G1

3

10

 G2

8

26

 G3

4

4

 unknown

0

5

0.265

(Mann–Whitney U test)

Tumor burden

MVI          absent

4

27

          present

11

18

0.037

(Fisher’s exact test)

EHS         absent

5

12

          present

10

33

0.743

(Fisher’s exact test)

MVI

and/or EHS      absent

1

5

          present

14

40

1.000

(Fisher’s exact test)

BCLC classification

 A

0

1

 B

1

0

 C

12

38

 D

2

4

 unknown

0

2

0.988

(Mann–Whitney U test)

ECOG PS

 0

2

9

 1

8

31

 2

2

3

 3

2

0

 unknown

1

2

0.099

(Mann–Whitney U test)

Child-Pugh

 A

1

13

 B

11

13

 C

0

4

 unkown

3

15

0.195

(Mann–Whitney U test)

Ascites

 absent

5

18

 present

6

13

 unknown

4

14

0.504

(Fisher’s exact test)

Baseline AFP (ng/ml)

 ≤20

2

20

 >20

11

25

 unknown

2

0

0.103

(Fisher’s exact test)

mean duration

sorafenib treatment

 days (standard deviation)

161 (126)

149 (128)

0.764

(unpaired t test)