Fig. 5
From: Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer
Hypo-methylated blocks associate with topological domains in the chromatin structure. a Boxplot of genomic distance (in bases) between TAD boundary (obtained from hESC) to nearest colon cancer HMB boundary. Distances between TADs and random 6 kb genomic regions are included as background. b Boxplots of average Hi-C interaction for bins within HMBs in hESC, with average interactions randomly generated genomic regions of similar size and GC content included as background. c same as (b) and for IMR90 cell line