Using gene expression from urine sediment to diagnose prostate cancer: development of a new multiplex mRNA urine test and validation of current biomarkers

Table 2 Univariate logistic regression and ROC analyses of the biomarkers

Variable	Fold change	Univariate logistic regression analysis		ROC analysis
Variable	Fold change	OR (95 % CI)	p value	AUC (95 % CI)
PCA3	1.331	4.106 (7.534–2.237)	<0.01*	0.708 (0.742–0.675)
ELF3	−1.676	0.637 (0.818–0.496)	<0.01*	0.657 (0.693–0.621)
MYO6	−1.270	0.561 (0.826–0.381)	0.003*	0.622 (0.659–0.585)
HIST1H2BG	−1.243	0.609 (0.852–0.435)	0.004*	0.613 (0.65–0.575)
GALNT3	−1.064	0.556 (0.955–0.324)	0.033*	0.583 (0.622–0.545)
PHF12	−1.074	0.68 (0.982–0.471)	0.04*	0.567 (0.606–0.528)
GDF15	−1.240	0.681 (0.995–0.466)	0.047*	0.594 (0.632–0.556)
PTOV1	−1.110	0.615 (1.028–0.368)	0.063	0.592 (0.63–0.554)
PSMA	1.108	1.99 (4.153–0.954)	0.067	0.59 (0.628–0.552)
SPINK1	−1.156	0.74 (1.046–0.524)	0.089	0.572 (0.611–0.534)
SOX4	−1.148	0.663 (1.065–0.413)	0.089	0.571 (0.61–0.533)
KLK12	−1.142	0.639 (1.091–0.375)	0.101	0.577 (0.615–0.538)
SLC44A5	−1.090	0.646 (1.122–0.372)	0.121	0.57 (0.609–0.532)
SPP1	1.241	1.126 (1.335–0.95)	0.171	0.543 (0.582–0.504)
DLX1	−1.169	0.718 (1.16–0.444)	0.175	0.562 (0.601–0.523)
CTHRC1	−1.178	0.724 (1.157–0.453)	0.177	0.556 (0.595–0.518)
TOX3	−1.057	0.677 (1.198–0.383)	0.18	0.56 (0.599–0.522)
TRPM4	−1.130	0.69 (1.217–0.391)	0.2	0.554 (0.592–0.515)
ELAVL2	−1.068	0.734 (1.186–0.454)	0.207	0.554 (0.593–0.515)
TWIST1	−1.120	0.744 (1.19–0.466)	0.217	0.558 (0.6–0.52)

Abbreviations: OD odds ratio, 95 % CI 95 % confidence interval, AUC Area Under the Curve
*Statistically significant (p < 0.05)
Note: Only biomarkers presenting a p value < 0.25 are listed. Univariate logistic regression and ROC analysis for all biomarkers is shown in Additional file 2: Table S2

ISSN: 1471-2407