Table 3 Univariate and multivariate analysis of factors associated with OS and RFS of 309 NSCLCs

Age

1.50

1.01–2.89

0.092

1.12

0.62–2.36

0.147

(≤65 vs. > 65)

Sex

1.09

0.61–1.79

0.671

0.86

0.43–1.58

0.704

(female vs. male)

Tobacco use

1.26

1.17–3.08

0.143

1.03

0.52–1.97

0.766

(no vs. yes)

TNM stage

3.25

1.66–5.91

0.0007

2.02

0.93–4.37

0.012

3.08

1.49–6.24

0.0009

2.27

1.09–5.45

0.010

(I vs. II–III)

pT status

1.65

0.88–2.89

0.070

1.22

0.57–2.39

0.198

(T1 vs. T2-4)

pN status

4.19

2.10–7.72

0.0005

2.34

1.02–5.99

0.005

3.55

1.71–7.23

0.0004

2.76

1.46–5.89

0.003

(N0 vs. N1-2)

Pleural involvement

0.77

0.31–1.52

0.830

0.67

0.39–1.43

0.902

(no vs. yes)

Differentiation (well/moderate vs. poor)

1.32

0.72–2.61

0.127

1.07

0.51–1.91

0.722

Foxc2 expression

1.98

0.75–3.92

0.036

1.90

0.76–4.05

0.039

2.13

1.08–4.15

0.011

1.54

0.89–3.67

0.077

(low vs. high)

E-cadherin expression

2.03

0.97–4.12

0.024

1.77

0.79–3.78

0.098

2.09

1.12–4.37

0.043

1.38

0.65–2.99

0.092

(preserved vs. impaired)

1 vs. 2

1.45

0.63–2.80

0.117

1.35

0.76–2.55

0.122

1 vs. 3

1.70

0.88–3.23

0.062

1.47

0.71–2.68

0.103

1 vs. 4

3.04

1.23–5.75

0.0009

2.41

1.12–4.67

0.002

2.55

1.29–5.16

0.008

2.06

0.87–4.17

0.035

1 vs. 2 + 3 + 4

1.85

0.90–3.53

0.026

1.34

0.64–2.23

0.168

1.56

0.74–3.05

0.071