From: Low-dose aspirin and survival from lung cancer: a population-based cohort study
Cancer-specific deaths | All patients | Person years | User versus non-user | User versus non-user | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | P | Adjusted HRa | P | P for interaction | ||||||
HRa | 95 % CI | HRa | 95 % CI | |||||||
Main analysis: Aspirin user versus non-user after diagnosis | 2,247 | 3,635 | 6,745 | 0.96 | 0.87, 1.05 | 0.36 | 0.96 | 0.85, 1.09 | 0.55 | |
Sub group analyses: Aspirin user versus non-user after diagnosis, restricted to: | ||||||||||
Males | 1,312 | 2,105 | 3,750 | 1.00 | 0.89, 1.12 | 0.97 | 1.05 | 0.90, 1.22 | 0.54 | 0.12 |
Females | 935 | 1,530 | 2,995 | 0.87 | 0.75, 1.02 | 0.08 | 0.81 | 0.66, 0.99 | 0.05 | |
Pre-diagnosis aspirin non-usersb | 1,515 | 2,446 | 4,578 | 0.89 | 0.74, 1.07 | 0.21 | 0.91 | 0.73, 1.14 | 0.42 | 0.48 |
Pre-diagnosis aspirin usersb | 554 | 908 | 1,601 | 0.92 | 0.72, 1.16 | 0.47 | 1.02 | 0.77, 1.35 | 0.90 | |
Small cell lung cancer | 328 | 424 | 592 | 0.84 | 0.66, 1.09 | 0.19 | 0.72 | 0.52, 1.01 | 0.05 | 0.03 |
Non-small cell lung cancer | 1,523 | 2,615 | 5,355 | 0.95 | 0.85, 1.06 | 0.35 | 1.00 | 0.86, 1.16 | 0.99 | |
Surgically treated | 305 | 872 | 2,714 | 0.99 | 0.78, 1.27 | 0.96 | 0.95 | 0.71,1.28 | 0.74 | 0.39 |
Non-surgically treated | 820 | 1,708 | 4,216 | 0.94 | 0.80, 1.10 | 0.42 | 0.89 | 0.74, 1.07 | 0.22 | |
Sensitivity analyses: Aspirin user versus non-user after diagnosis | ||||||||||
Increasing lag to 1 year | 2,247 | 3,635 | 6,745 | 0.97 | 0.88, 1.07 | 0.56 | 0.97 | 0.85, 1.10 | 0.60 | |
Excluding patients who died within the first 6 months after diagnosis | 4,440 | 6,158 | 9,101 | 0.96 | 0.90, 1.03 | 0.28 | 0.95 | 0.87–1.04 | 0.30 | |
Additionally adjusting for smoking prior to diagnosis | 2037 | 3,315 | 6,074 | 0.95 | 0.86, 1.04 | 0.28 | 0.95 | 0.84, 1.08 | 0.41 | |
Additionally adjusting for BMI prior to diagnosis | 1,849 | 3,048 | 5,640 | 0.93 | 0.84, 1.03 | 0.15 | 0.95 | 0.84, 1.09 | 0.47 | |
Additionally adjusting for small cell/non-small cell | 1,851 | 3,039 | 5,947 | 0.92 | 0.83, 1.03 | 0.14 | 0.92 | 0.80, 1.05 | 0.23 | |
Based upon first year after diagnosisc | 1,728 | 2,791 | 5,223 | 0.93 | 0.87, 1.05 | 0.33 | 0.99 | 0.88, 1.13 | 0.91 | |
Nested case–control analysisd,e | 2,247 | 0.93 | 0.85, 1.03 | 0.19 | 1.00 | 0.86, 1.16 | 0.97 |