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Table 3 Sept9 positivity of individuals with CRC

From: Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case–control study

  

1/3 algorithm

2/3 algorithm

Variable

 

P

N

% (95 % CI)

p*

P

N

% (95 % CI)

p*

  

93

35

73

NR

75

53

59

NR

Sex

Female

42

23

65 (52–76)

0.05

34

31

52 (40–65)

0.16

 

Male

51

12

81 (69–90)

 

41

22

65 ( 52–77)

 

Age

≤65

57

17

77 (66–86)

0.23

51

23

69 (59–81)

0.007

 

>65

36

18

67 (53–79)

 

24

30

44 (31–59)

 

Hypertension

No

60

21

74 (63–83)

0.68

49

32

60 (49–71)

0.58

 

Yes

33

14

70 (55–83)

 

26

21

55 (40–70)

 

Diabetes

No

84

33

72 (63–80)

0.73

67

50

57 (48–66)

0.36

 

Yes

9

2

82 (48–98)

 

8

3

73 (39–94)

 

Arteriosclerosis

No

80

28

74 (65–82)

0.42

65

43

60 (50–69)

0.46

Yes

13

7

65 (41–85)

 

10

10

50 (27–73)

 

Respiratory disease

No

87

30

74 (65–82)

0.17

71

46

61 (51–70)

0.20

Yes

6

5

55 (23–83)

 

4

7

36 (11–69)

 

Arthritis

No

91

29

76 (61–83)

0.005

73

47

61 (52–70)

0.07

 

Yes

2

6

25 (3–65)

 

2

6

25 (3–65)

 

Smoke#

No

38

9

81 (67–91)

0.08

29

18

62 (46–75)

0.36

 

Yes

55

26

68 (57–78)

 

46

35

57 (45–68)

 

Alcohol##

Normal use

78

25

76 (66–84)

0.14

64

39

62 (52–72)

0.12

 

Abuse

15

10

60 (39–79)

 

11

14

44 (24–65)

 

BMI

<18,5

3

1

75 (19–99)

0.97

3

1

75 (19–99)

0.95

 

18,5 to 25

52

18

74 (62–84)

 

41

29

59 (46–70)

 
 

25 to 30

27

12

69 (52–83)

 

22

17

56 (40–72)

 
 

>30

11

4

73 (45–92)

 

9

6

60 (32–84)

 

Tumor site

Left

23

7

77 (58–90)

0.67

17

13

57 (37–75)

0.70

 

Right

37

17

69 (54–80)

 

34

20

63 (49–76)

 
 

Rectum

33

11

75 (60–87)

 

24

20

55 (39–70)

 

MSI¤

Stable

35

15

70 (55–82)

1.00

28

22

56 (41–70)

1.00

 

Unstable

8

3

73 (39–94)

 

6

5

55 (23–83)

 

Plasma volume

< 3.5 ml

52

18

74 (62–84)

0.69

43

27

61 (49–73)

0.59

3.5 ml

41

17

71 (57–82)

 

32

26

55 (42–68)

 
  1. *p-value, two-sided Fisher’s exact test, p<0.05 considered statistically significant
  2. NR Not relevant, P Positive, N Negative, % Positive fraction detected
  3. #Former smokers and smokers pooled
  4. ##Abuse: Women > 7 units per week, Men >14 units per week
  5. ¤MSI determined by Immunohistochemistry, data not available on all cases