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Table 1 Clinicopathological parameters and survival analysis in 102 primary UPS tumors

From: Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

     

P

Variable

Group

No.

(%)

Analyzed groups

Overall survival

Event-free survival

Sex

Male

45

44.1

 

0.3077

0.1815

Female

57

55.9

Age (17 ~ 93, mean: 62)

<62

53

52

 

0.3714

0.1518

≧62

49

48

Size

<5 cm

35

34.3

 

0.0058a

0.0008a

≧5 cm

56

54.9

N/A

11

10.8

Location

Superficial

42

41.2

 

0.0154a

0.0193a

Deep

54

52.9

NA

6

5.9

Chemotherapy

Yes

20

19.6

 

0.5761

0.9270

No

30

29.4

NA

52

51.0

Surgical margin

Positive

18

17.6

 

0.3069

0.9937

Negative

45

44.1

NA

39

38.3

Metastasis

+

28

27.5

 

<0.0001a

<0.0001a

-

74

72.5

Reccurence

+

16

15.7

 

0.9212

<0.0001a

-

86

84.3

Necrosis

0, score 0

58

56.9

Score 0 vs others

0.0011a

0.0101a

<50 %, score 1

31

30.4

Score 1 vs score 2

0.464

0.6221

≧50 %, score 2

13

12.7

Score 2 vs others

0.0344a

0.2112

Mitosis

0–9/10 HPF, score 1

53

52

Score 1 vs others

0.0003a

0.0005a

10–19/10 HPF, score 2

28

27.4

Score 2 vs score 3

0.0291a

0.4872

20≧/10 HPF, score 3

21

20.6

Score 3 vs others

<0.0001a

0.0077a

MIB-1 LI

<10 %

20

26.7

 

0.0569

0.0533

≧10 %

50

66.7

 

NA

5

6.6

 

FNCLCC

2

64

62.7

 

<0.0001a

00002a

3

38

37.3

 

AJCC 7th ed

II

59

57.8

Stage II vs others

<0.0001a

<0.0001a

III

15

14.7

Stage III vs IV

0.0614

<0.0001a

IV

28

27.5

   
  1. AJCC American Joint Committee on Cancer, FNCLCC French Federation of Cancer Centers, HPF high-power fields, LI labeling index, N/A not available, No. number of patients. The Fisher exact test or the log-rank test was used if not indicated otherwise
  2. aStatistically significant