Fig. 1From: KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcomeKIT maturation and activation status and related intracellular signaling in KIT-expressing cells treated or not with imatinib. Western blotting analysis after a 24-h exposure to 1 μM of imatinib of the expression and the phosphorylation of a. mature (145 kDa) and immature (125 kDa) forms of KIT on residues Tyr703 and Tyr823 and b. AKT, RAF and ERK1/2Back to article page