Fig. 4

KDI – Knowledge and Data Integration. Integration of heterogeneous clinical and biological/molecular data requires a powerful information system. Data integration: all data (clinical data from eCRF, biological data, including tumor microenvironment (TME) analysis using immunohistochemistry (IHC) and HPV typing and raw data from technological platforms: exome and targeted sequencing on gDNA and ctDNA, reverse phase protein analysis (RPPA)) will be integrated into KDI core system. Afterwards advanced research functionalities will enable multiple data queries. Specific bioinformatics pipelines will generate new integrative knowledge from these heterogeneous sources of data (figure adapted from Servant et al. [22])