Table 3 Metabolic and endocrine parameters at baseline (before randomization) and day 0 (immediately before chemotherapy infusion during the use of prophylactic dexamethasone)
Parameter | N | Baseline Median (range) | Day 0 (with DEX) Median (range) | In/decrease | P value |
Glucose (3.1-6.4 mmol/L) | STF (n = 5) | 5.2 (4.3-5.5) | 6.8 (5.6-9.0) | ↑ | 0.042 |
Non-STF (n = 5) | 4.8 (4.7-6.7) | 7.0 (6.1-8.8) | ↑ | 0.043 | |
Insulin (0-20 mU/L) | STF (n = 5) | 14.0 (2.0-40.0) | 13.0 (6.0-36.0) | = | 0.500 |
Non-STF (n = 5) | 2.0 (2.0-9.0) | 16.0 (9.0-63.0) | ↑ | 0.043 | |
Parameter | N | Baseline Mean (SE) | Day 0 (with DEX) Mean (SE) | In/decrease | P value |
IGF-1 (5.4-24.3 nmol/L) | STF (n = 4) | 23.7 (2.9) | 19.6 (3.3) | ↓ | 0.012 |
Non-STF (n = 5) | 17.5 (3.5) | 16.8 (2.8) | = | 0.634 | |
IGF-BP3 (2.2-5.8 mg/L) | STF (n = 4) | 5.0 (0.5) | 4.2 (0.3) | = | 0.212 |
Non-STF (n = 5) | 4.5 (0.2) | 3.9 (0.3) | = | 0.122 | |
TSH (0.3-4.8 mU/L) | STF (n = 3) | 1.38 (0.26) | 0.61 (0.08) | = | 0,065 |
Non-STF (n = 5) | 1.49 (0.14) | 0.42 (0.06) | ↓ | 0.034 | |
FT4 (12-22pmol/L) | STF (n = 3) | 15.4 (0.92) | 13.9 (0.94) | = | 0.117 |
Non-STF (n = 5) | 15.0 (0.54) | 14.0 (0.34) | = | 0.149 |