Table 7 CLART, LA, and HC2: sensitivity and specificity for ≥ CIN2 and ≥ CIN3

Endpoint: ≥CIN2

Sensitivity (95% CI)

0.93 (0.87-0.97)

0.96 (0.91-0.99)

0.98 (0.94-1.00)

Relative sensitivity vs. LA

0.97 (0.91-1.03)

1.0 (ref)

1.03 (0.98-1.07)

Relative sensitivity vs. HC2

0.94 (0.89-1.00)

0.98 (0.94-1.02)

1.0 (ref)

Specificity

0.30 (0.25-0.36)

0.26 (0.21-0.32)

0.17 (0.12-0.22)

Relative Specificity vs. LA

1.16 (0.88-1.54)

1.0 (ref)

0.64 (0.46-0.90)

Relative Specificity vs. HC2

1.81 (1.30-2.52)

1.56 (1.11-2.19)

1.0 (ref)

Endpoint ≥ CIN3

Sensitivity (95% CI)

0.93 (0.86-0.98)

0.97 (0.91-0.99)

0.99 (0.94-1.00)

Relative sensitivity vs. LA

0.97 (0.90-1.03)

1.0 (ref)

1.02 (0.98-1.07)

Relative sensitivity vs. HC2

0.94 (0.89-1.00)

0.98 (0.94-1.02)

1.0 (ref)

Specificity

0.28 (0.23-0.33)

0.23 (0.19-0.29)

0.15 (0.11-0.20)

Relative Specificity vs. LA

1.17 (0.89-1.55)

1.0 (ref)

0.64 (0.45-0.90)

Relative Specificity vs. HC2

1.84 (1.32-2.56)

1.57 (1.11-2.21)

1.0 (ref)