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Table 1 Cytotoxic activities of cyproheptadine in HCC cell lines after 24 h of treatment

From: Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase

IC50(µM)a

Selectivity index (SIb)

HHc

HepG2

Huh-7

HepG2

Huh-7

118.1 ± 6.4

44.4 ± 6.1

44.7 ± 6.1

2.7

2.6

  1. aData are expressed as the means ± SD of ≥4 replicates.
  2. bAn SI value >2.6 indicates a high degree of cytotoxic selectivity.
  3. cNormal human hepatocytes.
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BMC Cancer

ISSN: 1471-2407

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