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Table 3 Distribution of NAT1 and NAT2 acetylation polymorphisms and association with OSCC in the Black and Mixed Ancestry populations

From: NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study

  

Black

Mixed Ancestry

Gene

Acetylator status

Controls (%)

Cases (%)

OR (95% CI)a

P-value

Controls (%)

Cases (%)

OR (95% CI)a

P-value

NAT2

Rapid

87 (18)

90 (19)

1 (Ref)

 

49 (17)

57 (21)

1 (Ref)

 

Intermediate

231 (48)

192 (41)

0.77 (0.50-1.20)

0.248

124 (43)

113 (42)

0.47 (0.28-0.80)

0.004

Slow

155 (32)

161 (35)

0.88 (0.56-1.39)

0.588

115 (40)

91 (34)

0.40 (0.24-0.68)

0.001

Unknown

7 (1)

20 (4)

  

0 (0)

8 (3)

  

Slow + intermediate

386 (82)

353 (79)

0.82 (0.54-1.23)

0.333

239 (83)

204 (78)

0.44 (0.27-0.70)

0.001

NAT1

Rapid

155 (32)

142 (31)

1 (Ref)

 

50 (17)

47 (17)

1 (Ref)

 

Intermediate

219 (46)

196 (42)

0.72 (0.49-1.05)

0.084

128 (44)

130 (48)

1.04 (0.50-2.17)

0.908

Slow

89 (18)

100 (22)

0.94 (0.59-1.48)

0.781

106 (37)

81 (30)

0.64 (0.29-1.37)

0.249

Unknown

17 (3)

25 (5)

  

4 (1)

11 (4)

  

Slow + intermediate

308 (66)

296 (68)

0.78 (0.55-1.11)

0.166

234 (82)

211 (81)

0.85 (0.43-1.68)

0.638

  1. aOdds ratio was adjusted for age, gender, tobacco smoking, and alcohol consumption status.
  2. Ref = reference allele.
  3. NAT2 rapid = NAT2*4/*4.
  4. NAT2 intermediate = NAT2*4/*5, NAT2*4/*6, NAT2*4/*7, or NAT2*4/*14.
  5. NAT2 slow = any combination of NAT2*5, NAT2*6, NAT2*7, and NAT2*14.
  6. NAT1 rapid = NAT1*10/*10.
  7. NAT1 intermediate = NAT1*10/*4 or NAT1*10/*3.
  8. NAT1 slow = NAT1*4/*4, NAT1*4/*3, or NAT1*3/*3.
  9. *Indicates the allele for each of the genes.
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BMC Cancer

ISSN: 1471-2407

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