Figure 5
From: Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure
Invasive lesions show decreased e-cadherin. Schematic (A) and confocal slice (B-D) of bottom of DCIS model cocultured with HMFs for 5 days and stained for e-cadherin (red) and nuclei (blue). A magnified view of a less invasive region (C) compared to a more invasive region (D) indicate that e-cadherin is down regulated in cells that have undergone the invasive transition. Scale bars represent 50 μm.