Figure 7
From: A reproducible brain tumour model established from human glioblastoma biopsies
MRI monitoring shows that brain tumour growth can be standardised and that the phenotypes are modulated with passaging in vivo. Coronary MRI scans showing tumour growth in four rats grafted with tissue from the same patient biopsy. Shown are T2 sequences at 3 different time points as indicated, while the right column present T1 images after administering contrast agent (A). MRI scans demonstrating different brain tumour phenotypes (B), displaying angiogenic and invasive growth as indicated (bottom). Corresponding H/E stained tumour sections are shown below the MRI panels. Extended passaging provide 3 distinct phenotypes that represent different combinations of invasive and angiogenic growth patterns.