Figure 4

Hierarchical clustering of all samples using literature signatures. The number of genes common between our data set and each specific signature is reported in brackets. The dendrogram for clustering was obtained using centered correlation and average linkage. Patient ID and time elapsed between surgical removal and freezing are reported for each sample. The stability of our clusters (at a correlation level r>0.2) was investigated exploiting a BRB algorithm which performs 100 permutations of data and calculates an R index ranging between 0 and 1 where 0 indicates non reproducibility and 1 complete reproducibility. R index values are reported for each single clustering result.