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Table 2 AFB1 exposure and the risk of HCC

From: XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk

 

Controls

HCCs

   

AFB1 exposure

n

%

n

%

OR (95% CI)

Adjusted OR (95% CI)

P trend

AFB1-exposure yearsa, b

   Short

378

53.1

130

21.0

Reference

Reference

 

   Medium

197

27.7

196

31.7

2.89 (2.19-3.83)

9.08(6.07-13.57)c

< 0.001

   Long

137

19.2

292

47.2

6.20 (4.66-8.24)

156.03(77.83-312.77)c

< 0.001

AFB1-DNA adducts levelsd, e

   Low

380

53.4

153

24.8

Reference

Reference

 

   Medium

209

29.4

172

27.8

2.04(1.55-2.69)

2.11(1.54-2.90)f

< 0.001

   High

123

17.3

293

47.4

5.92(4.46-7.84)

6.23(4.48-8.67)f

< 0.001

  1. a The Median for AFB1-exposure years were 48 years and 40 years for cases and controls, respectively.
  2. b AFB1-exposure years were: < 40 years for short exposure; 40 - 48 years for medium exposure; > 48 years for long exposure.
  3. c Adjusted for age, sex, ethnicity, HBsAg, anti-HCV, and AFB1-DNA adducts levels.
  4. d The mean ± S.E. level of AFB1-DNA adducts is 1.97 ± 0.05 and 1.04 ± 0.02 μmol/mol DNA for cases and controls, respectively.
  5. e Adduct levels were: ≤ 1.00 μmol/mol DNA for low level; 1.01 -- 2.00 μmol/mol DNA for medium; ≥ 2.01 μmol/mol DNA for high level.
  6. f Adjusted for age, sex, ethnicity, HBsAg, anti-HCV, and AFB1-exposure years.
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BMC Cancer

ISSN: 1471-2407

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