Table 2 Univariate and multivariate COX regression analysis

Egr-1

Low expression (score 1) versus Egr-1 negative (score 0)

1.59 (1.01-2.50)

0.044

1.41 (0.89-2.24)

0.143

Moderate-high expression (score 2-3) versus Egr-1 negative (score 0)

1.95 (1.11-3.44)

0.021

1.38 (0.76-2.49)

0.285

Age (5 year intervals)

1.19 (1.08-1.31)

0.001

1.11 (0.99-1.25)

0.078

Tumor type (Papillary versus solid/mixed)

2.33 (1.43-3.80)

0.001

1.78 (1.03-3.08)

0.038

Tumor stage (T1 versus Ta)

3.01 (2.07-4.38)

<0.001

0.42 (0.16-1.10)

0.078

Tumor grade (High grade versus PUNLMP+low grade)

3.42 (2.34-4.98)

<0.001

6.12 (2.27-16.55)

0.000

Sex

0.99 (0.63-1.56)

0.981

Size (> 3 cm versus < 3 cm)

1.02 (0.65-1.60)

0.941

Bacillus Calmette-Guerin (BCG) treatment

0.55 (0.32-0.93)

0.026

Concomitant CIS

1.02 (0.65-1.60)

0.941