From: CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection
Clinicopathological parameters | p53 over-expression in HCC | Unadjusted OR (95% CI)a | Adjusted OR (95% CI)b | |
---|---|---|---|---|
 | Positive (n = 25) | Negative (n = 129) |  |  |
Age (years) | 52.5 ± 14.8 | 56.8 ± 15.0 | 0.985 (0.958 - 1.013) | 0.995 (0.942 - 1.050) |
Sex (male) | 23 (92.0%) | 91 (70.5%) | 4.802 (1.019 - 31.022)c | 10.217 (0.861 - 121.307) |
HBsAg (positive) | 22 (88.0%) | 82 (63.6%) | 4.203 (1.110 - 18.673)d | 1.490 (0.130 - 17.10) |
Anti-HCV (positive) | 4 (16.0%) | 38 (29.5%) | 0.456 (0.123 - 1.537) | 0.791 (0.074 - 8.490) |
Cirrhosis (yes) | 14 (56.0%) | 59 (45.7%) | 1.510 (0.590 - 3.893) | 1.639 (0.396 - 6.783) |
Alcoholism (yes) | 5 (20.0%) | 38 (29.5%) | 0.599 (0.182 - 1.857) | 0.269 (0.052 - 1.390) |
Creatinine (mg/dL) | 1.0 ± 0.2 | 1.2 ± 1.0 | 0.614 (0.193 - 1.954) | 0.106 (0.003 - 4.139) |
Tumor characteristics | Â | Â | Â | Â |
   Microvascular invasion (yes) | 10 (40.0%) | 36 (27.9%) | 1.722 (0.647 - 4.547) | 1.658 (0.249 - 11.043) |
   Edmondson's grading (> 2) | 15 (60.0%) | 93 (72.1%) | 0.581 (0.220 - 1.545) | 1.800 (0.404 - 8.019) |
   Encapsulation (yes) | 18 (72.0%) | 98 (76.0%) | 0.813 (0.286 - 2.381) | 0.600 (0.097 - 3.691) |
   Tumor number (> 2) | 4 (16.0%) | 26 (20.2%) | 0.755 (0.200 - 2.609) | 0.566 (0.080 - 4.008) |
   Microsatellites (yes) | 3 (12.0%) | 24 (18.6%) | 0.597 (0.130 - 2.349) | 2.520 (0.213 - 29.798) |
   Tumor size (Diameter, cm) | 9.3 ± 9.5 | 6.9 ± 4.7 | 1.008 (0.920 - 1.104) | 0.781 (0.590 - 1.034) |
   Portal Vein Thrombosis (yes) | 6 (24.0%) | 53 (41.1%) | 0.453 (0.150 - 1.308) | 4.645 (0.368 - 58.611) |
   Alpha-fetoprotein (100 ng/mL) | 10.2 ± 27.5 | 62.0 ± 323.9 | 0.995 (0.982 - 1.008) | 0.991 (0.967 - 1.016) |
Liver Function | Â | Â | Â | Â |
   Albumin (g/dL) | 3.7 ± 0.7 | 3.8 ± 0.7 | 0.860 (0.436 - 1.699) | 2.560 (0.644 - 10.184) |
   Bilirubin (mg/dL) | 1.2 ± 0.8 | 1.3 ± 1.8 | 0.950 (0.688 - 1.310) | 0.591 (0.273 - 1.283) |
   Prothrombin time (sec) | 12.5 ± 1.9 | 12.4 ± 1.5 | 1.049 (0.798 - 1.379) | 1.146 (0.752 - 1.745) |
   Ascites (yes) | 3 (12.0%) | 11 (8.5%) | 1.463 (0.296 - 6.358) | 4.545 (0.613 - 33.665) |
Liver necroinflammation | Â | Â | Â | Â |
   AST (U/L) | 132.0 ± 210.7 | 88.7 ± 89.0 | 1.002 (0.999 - 1.006) | 1.017 (1.005 - 1.030) |
   ALT (U/L) | 90.4 ± 127.8 | 74.1 ± 91.0 | 1.001 (0.996 - 1.005) | 0.985 (0.972 - 0.999) |
   CD133 expression | 2 (8.0%) | 22 (17.1%) | 0.423 (0.064 - 2.064) | 0.537 (0.055 - 5.202) |