From: CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection
Clinicopathological parameters | CD133 expression in HCC | Unadjusted OR (95% CI)a | Adjusted OR (95% CI)b | |
---|---|---|---|---|
 | Positive (n = 24) | Negative (n = 130) |  |  |
Age (years) | 53.6 ± 15.3 | 56.7 ± 14.9 | 0.983 (0.959 - 1.010) | 0.997 (0.943 - 1.055) |
Sex (male) | 18 (75.0%) | 96 (74.8%) | 1.063 (0.358 - 3.282) | 0.621 (0.109 - 3.542) |
HBsAg (positive) | 11 (45.8%) | 93 (71.5%) | 0.337 (0.126 - 0.890)c | 0.084 (0.010 - 0.707)d |
Anti-HCV (positive) | 6 (25.0%) | 36 (27.7%) | 0.870 (0.283 - 2.575) | 0.295 (0.027 - 3.192) |
Cirrhosis (yes) | 11 (45.8%) | 62 (47.7%) | 0.928 (0.356 - 2.410) | 1.630 (0.324 - 8.188) |
Alcoholism (yes) | 6 (25.0%) | 37 (28.5%) | 0.838 (0.272 - 2.474) | 1.135 (0.212 - 6.061) |
Creatinine (mg/dL) | 1.0 ± 0.2 | 1.3 ± 1.6 | 0.324 (0.048 - 2.202) | 0.849 (0.167 - 4.305) |
Tumor characteristics | Â | Â | Â | Â |
   Microvascular invasion (yes) | 11 (45.8%) | 35 (26.9%) | 2.297 (0.862 - 6.110) | 10.560 (1.312 - 84.994) |
   Edmondson's grading (> 2) | 18 (75.0%) | 77 (59.2%) | 2.065 (0.710 - 6.271) | 6.315 (0.758 - 52.618) |
   Encapsulation (yes) | 17 (70.8%) | 99 (76.2%) | 0.760 (0.265 - 2.243) | 1.775 (0.285 - 11.055) |
   Tumor number (> 2) | 9 (37.5%) | 21 (16.2%) | 3.114 (1.088 - 8.867)e | 2.933 (0.561 - 15.334) |
   Microsatellites (yes) | 7 (29.2%) | 20 (15.4%) | 2.265 (0.740 - 6.794) | 2.032 (0.185 - 22.347) |
   Tumor size (Diameter, cm) | 8.0 ± 5.2 | 6.7 ± 4.6 | 1.057 (0.970 - 1.152) | 0.881 (0.700 - 1.110) |
   Portal Vein Thrombosis (yes) | 3 (12.5%) | 10 (7.7%) | 1.741 (0.341 - 7.616) | 0.893 (0.094 - 8.487) |
   Alpha-fetoprotein (100 ng/mL) | 70.3 ± 394.6 | 31.3 ± 55.6 | 1.000 (0.997 - 1.002) | 0.996 (0.988 - 1.003) |
Liver Function | Â | Â | Â | Â |
   Albumin (g/dL) | 3.7 ± 0.6 | 3.8 ± 0.7 | 0.881 (0.446 - 1.742) | 1.493 (0.409 - 5.456) |
   Bilirubin (mg/dL) | 1.2 ± 0.9 | 1.3 ± 1.8 | 0.950 (0.688 - 1.310) | 1.032 (0.588 - 1.812) |
   Prothrombin time (sec) | 12.2 ± 1.2 | 12.5 ± 1.6 | 0.876 (0.623 - 1.232) | 0.905 (0.563 - 1.456) |
   Ascites (yes) | 2 (8.3%) | 12 (9.2%) | 0.894 (0.129 - 4.693) | 1.140 (0.103 - 12.576) |
Liver necroinflammation | Â | Â | Â | Â |
   AST (U/L) | 117.3 ± 202.2 | 91.1 ± 98.3 | 1.002 (0.998 - 1.005) | 1.009 (0.998 - 1.019) |
   ALT (U/L) | 72.3 ± 116.9 | 75.6 ± 91.9 | 1.000 (0.995 - 1.005) | 0.997 (0.987 - 1.007) |