Table 2 Distribution of protein expression of the apoptotic and antiapoptotic markers, Cox proportional hazard ratios (HR) and 95% confidence intervals (CI) for overall survival by the biomarker status for ESCC patients.
From: Biomarkers of apoptosis and survival in esophageal squamous cell carcinoma
Gene protein | N1 | Distribution of protein expression by overall score (N, prevalence)2 | HR3 (95% CI) P-value | Number (prevalence) with positive protein expression score4 | HR5 (95% CI) P-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Score | |||||||||||||
0 | 1 | 2 | 3 | 4 | 6 | 8 | 9 | 12 | |||||
FasL | 244 | 15 (0.06) | 48 (0.20) | 92 (0.38) | 80 (0.33) | 3 (0.01) | 6 (0.03) | --- | --- | --- | 1.10 (0.95-1.27) 0.45 | 9 (0.04) | 1.04 (0.45-2.40) 0.92 |
Fas | 244 | 24 (0.10) | 49 (0.20) | 44 (0.18) | 91 (0.37) | 8 (0.03) | 22 (0.09) | --- | 5 (0.02) | 1 (0.00) | 0.95 (0.87-1.04) 0.07 | 36 (0.15) | 0.79 (0.49-1.27) 0.32 |
FADD | 248 | 10 (0.04) | 122 (0.49) | 72 (0.29) | 8 (0.03) | 17 (0.07) | 12 (0.05) | 4 (0.02) | 1 (0.00) | 2 (0.01) | 1.05 (0.96-1.14) 0.79 | 36 (0.15) | 1.22 (0.77-1.92) 0.39 |
pFADD | 247 | 190 (0.77) | 48 (0.19) | 9 (0.04) | --- | --- | --- | --- | --- | --- | 1.02 (0.76-1.38) 0.25 | 0 (0.00) | --- |
Caspase 8 | 244 | 11 (0.05) | 76 (0.31) | 144 (0.59) | --- | 11 (0.05) | 2 (0.01) | --- | --- | --- | 0.92 (0.76-1.11) 0.53 | 13 (0.05) | 1.03 (0.51-2.05) 0.94 |
Caspase 10 | 235 | 6 (0.03) | 47 (0.20) | 161 (0.69) | --- | 17 (0.07) | 3 (0.01) | --- | 1 (0.00) | --- | 1.07 (0.93-1.23) 0.46 | 21 (0.09) | 1.36 (0.81-2.27) 0.25 |
Bcl2 | 253 | 23 (0.09) | 167 (0.66) | 58 (0.23) | --- | 5 (0.02) | --- | --- | --- | --- | 1.01 (0.81-1.27) 0.63 | 5 (0.02) | 1.29 (0.52-3.25) 0.58 |