Characterization of SV-40 Tag rats as a model to study prostate cancer

BMC Cancer

Table 2 Biomarker protein expressions in the prostate lobes of 12 week old non-transgenic and SV-40 Tag rats

	Non-transgenic Ventral Prostate	SV-40 Tag Ventral Prostate	Non-transgenic Dorsolateral Prostate	SV-40 Tag Dorsolateral Prostate
Androgen Receptor	100 ± 12	185 ± 22*	100 ± 7	116 ± 11
Estrogen Receptor-alpha	100 ± 6	49 ± 7*	100 ± 9	51 ± 7*
Insulin-like Growth Factor-1	100 ± 3	110 ± 4*	100 ± 2	146 ± 6*
Insulin-like Growth Factor-1-alpha Receptor	100 ± 3	253 ± 32*	100 ± 6	138 ± 3*
Total-Extracellular Regulating Kinase-1	100 ± 5	302 ± 64*	100 ± 19	174 ± 21*
Total-Extracellular Regulating Kinase-2	100 ± 4	298 ± 58**	100 ± 16	157 ± 16*

Protein expressions were determined by immunoblot analysis, except for IGF-1 levels that were determined by ELISA (n = 6 per group). Protein expressions for non-transgenic rats were set to 100 and those of transgenic rats are presented as percent of non-transgenic rats ± SEM. *P < 0.05 and **P < 0.01 compared to non-transgenic rats by two-tailed Students t test.

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