Figure 1

Expressions of THBS1, Cyr61 and CTGF in normal human esophageal epithelium and ESCC. Staining of the three genes was performed as indicated in Materials and Methods. Scale bar represents 100 μm in the tissue core shown in panel A-F. THBS1 (A), Cyr61 (B) and CTGF (C) in ESCC demonstrated strong cytoplasmic staining which was scored as over-expression. THBS1 (B), Cyr61 (C) and CTGF (D) in normal esophageal epithelium showed weak or absent staining and were scored as non-overexpression.