Figure 6
Quantitation of mRNA levels of c-myc in the liver at week 8 and 15 in model, 1%, 2% and 4% betaine groups. Results were expressed relative to the control group. Compared with the control group, the mRNA levels of c-myc in the model group were increased after 8 weeks (P < 0.001) and 15 weeks (P < 0.001). Betaine significantly decreased the up-regulation of c-myc expression induced by DEN in a concentration-dependent manner (P < 0.01). Data are means ± SD. Different letter (such as "a" versus "b") on the top of each bar indicates P < 0.05 between them.