Figure 5
From: Role of KCNMA1gene in breast cancer invasion and metastasis to brain
KCNMA1 expression promotes breast cancer cell invasion. A: Representative images of breast cancer cells that have migrated through the Matrigel coated transwell and adhered to the lower surface of the filters. The migrated cells were stained with crystal violet (see arrows). B: Breast cancer cells pretreated with IBTX or siRNA to silence the KCNMA1 gene demonstrated significantly (*P < 0.03; **P < 0.001) reduced BKCa channel mediated invasion compared to untreated breast cancer cell lines. Data are expressed as percentage of migration in the untreated controls (100%). Bars represent mean ± the standard error of the mean obtained from three different experiments (n = 3).