Figure 5

Amphiregulin and COX-2 dependent cell growth in colon cancer cells. Bar chart shows the effect on cell proliferation (as assessed by BrdU Incorportion) of a neutralising antibody to amphiregulin (ARab, 10 mg/ml), a COX-2 inhibitor (SC-236, 5 μM) or a combination of both for 24 hours. Values shown are the Mean +/- SEM for n = 5. One way ANOVA (overall) p = 0.0001, p values shown are for Bonferroni multiple comparisons test between selected groups.