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Table 2 The cytotoxicity of DM4 and AVE9633 in K562, HL60 and their variant cell lines expressing P-gp in the presence or absence of the P-gp modulator Zosuquidar

From: P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

IC50

HL60

HL60/DNR

K562

K56/HHT40

K562/HHT90

K562/DOX

AVE9633 (nM)

19.9 ± 0.7

> 800

    

AVE9633 + Zosuquidar

20.1 ± 1.1

10.4 ± 2.1

    

DM4 (nM)

14.8 ± 0.3

> 800

11.8 ± 1.1

18.4 ± 1.2

36.6 ± 2.0

437.6 ± 15.1

DM4 + Zosuquidar

18.3 ± 1.3

10.9 ± 0.1

12.6 ± 1.2

6.5 ± 0.6

10.1 ± 0.8

11.6 ± 0.9

  1. * Zosuquidar: 0.3 μM
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BMC Cancer

ISSN: 1471-2407

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