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Table 2 NFKBIA and NFKBIB Polymorphisms and Adjusted Risk of Epithelial Ovarian Cancer

From: Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer

    

General Model OR (95%CI)

Ordinal Model OR (95% CI)

Gene

SNP ID

bp to next

MAF

AB v AA

BB v AA

p-value

per-allele

p-value

NFKBIA

rs3138055

639

0.28

0.99 (0.81–1.20)

1.02 (0.72–1.46)

0.98

1.00 (0.87–1.16)

0.99

 

rs696

124

0.38

0.94 (0.77–1.15)

0.85 (0.64–1.14)

0.54

0.93 (0.81–1.06)

0.28

 

rs8904

190

0.38

0.93 (0.76–1.13)

0.84 (0.63–1.13)

0.49

0.92 (0.80–1.05)

0.24

 

rs1022714

900

0.21

0.94 (0.78–1.15)

0.98 (0.61–1.59)

0.85

0.96 (0.82–1.13)

0.65

 

rs3138054

485

0.17

1.18 (0.97–1.44)

0.97 (0.51–1.85)

0.26

1.13 (0.94–1.35)

0.19

 

rs2233415

978

0.27

0.84 (0.69–1.02)

0.93 (0.65–1.32)

0.22

0.91 (0.78–1.05)

0.20

 

rs1957106

500

0.30

0.77 (0.63–0.94)

0.92 (0.65–1.30)

0.03

0.87 (0.76–1.01)

0.07

 

rs2233409

253

0.23

1.11 (0.92–1.35)

0.93 (0.61–1.40)

0.48

1.04 (0.89–1.21)

0.61

 

rs2233407

331

0.06

1.27 (0.96–1.70)

0.24 (0.04–1.24)

0.06

1.13 (0.86–1.47)

0.38

 

rs3138053

515

0.29

1.03 (0.85–1.25)

1.06 (0.75–1.49)

0.93

1.03 (0.89–1.19)

0.70

 

rs3138050

2,352

0.22

1.04 (0.77–1.40)

2.28 (1.10–4.73)

0.09

1.20 (0.94–1.54)

0.14

 

rs3138045

5,214

0.22

1.00 (0.82–1.22)

1.25 (0.80–1.97)

0.62

1.05 (0.89–1.23)

0.56

 

rs2007960

---

0.39

1.03 (0.84–1.26)

1.02 (0.78–1.34)

0.96

1.01 (0.89–1.16)

0.83

NFKBIB

rs2053071

886

0.35

0.87 (0.71–1.06)

1.08 (0.80–1.46)

0.22

0.99 (0.86–1.13)

0.86

 

rs12979755

3,098

0.39

0.99 (0.81–1.21)

0.99 (0.75–1.31)

0.99

0.99 (0.87–1.14)

0.93

 

rs8108039

3,501

0.19

0.99 (0.81–1.21)

1.40 (0.82–2.38)

0.44

1.05 (0.89–1.24)

0.57

 

rs3136642

233

0.39

1.03 (0.84–1.26)

1.05 (0.80–1.39)

0.93

1.03 (0.90–1.17)

0.71

 

rs3136645

628

0.20

1.02 (0.83–1.24)

1.23 (0.76–1.99)

0.70

1.05 (0.89–1.24)

0.56

 

rs3136646

---

0.22

0.99 (0.81–1.21)

0.78 (0.51–1.18)

0.49

0.94 (0.80–1.10)

0.41

  1. Adjusted for race, age, area of residence, body mass index, hormone therapy use, oral contraceptive use, parity, and age at first birth; NFKBIA rs3138050 exclude Duke University participants; MAF, minor allele frequency among controls; bold = < 0.05; bp to next represents distance in base pairs between SNPs.
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BMC Cancer

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