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Table 3 Differentially expressed genes associated with cervical lymph node and pathologic stage status

From: Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis

p-value

Number present

t-score

Accession: Definition/Description or EST name

0.001%

30

5.324

M20681: Human glucose transporter-like protein-III (Glu3)

0.006%

10

4.525

X71125: H. sapiens mRNA for glutamine cyclotransferase

0.011%

10

3.943

X51757: HAP70B Human heat-shock protein HSP70B gene

0.014%

16

4.519

AB028957: H. sapiens mRNA for KIAA1034 protein

0.025%

26

4.261

Protein Phosphatase inhibitor homolog

0.021%

30

4.568

Y12065: H. Sapiens mRNA for nucleolar protein hNop56

0.031%

29

4.272

AB015633: Homo sapiens mRNA for type II membrane protein

0.031%

8

4.517

D78579: Homo sapiens mRNA for neuron derived orphan receptor

0.031%

17

3.764

W25985: 17e6

0.044%

31

3.792

AF007140: Homo sapiens clone 23711 unknown mRNA

0.061%

31

3.659

X86163: H. sapiens mRNA for B2-bradykinin receptor

0.064%

31

3.706

A1935420: wo84c08

0.076%

8

3.188

AB020654: Homo sapiens mRNA for KIAA0847 protein

0.076%

7

3.246

L23959: HUMDP1A Homo sapiens E2F-related transcription factor (DP-1) mRNA

0.090%

31

2.808

AL09674: Homo sapiens mRNA: cDNA DKFZp58600223

0.090%

21

3.544

Z11697: Homo sapiens mRNA for HB 15

0.090%

22

3.813

X98834: H. sapiens mRNA for zinc finger protein, Hsal2

0.106%

16

3.720

M81750: H. sapiens myeloid cell nuclear differentiation antigen mRNA

0.106%

25

3.943

S68134: CREM = cyclic AMP-responsive element modulator beta isoform

0.125%

31

3.302

X98296: H. sapiens mRNA for ubiquitin hydrolase

0.147%

26

3.051

U49392: Human allograft inflammatory factor-1 (AIF-1) mRNA

0.193%

7

3.269

AL109669: Homo sapiens mRNA full length insert cDNA clone EUROIMAGE

0.195%

5

2.861

M31166: HUMTSG14A Human tumor necrosis factor-inducible (TSG-14) mRNA

A

   

p-value

Number present

t-score

Accession: Definition/Description or EST name

0.016%

31

4.286

AA402538: Soares ovary tumor NbHOT Homo sapiens cDNA

0.035%

22

3.690

X98834: H. sapiens mRNA for zinc finger protein, Hsal2

0.035%

26

3.501

U49392: Human allograft inflammatory factory-1 (ALF-1) mRNA

0.043%

5

3.782

X62055: H. sapiens PTP1C mRNA for protein-tyrosine phosphate

p-value

Number present

t-score

Accession: Definition/Description or EST name

0.062%

11

3.514

AB023135: Homo sapiens mRNA for activation-inducible lymphocyte

   

immunomediatory molecule AILIM

0.062%

31

3.698

A1828166: wk32h09

0.073%

31

3.761

U85773: Human phosphomannomutase (PMM2) mRNA

0.085%

6

3.501

S67970: ZNF75 = KRAB zinc finger [human, lung fibroblast, mRNA

0.104%

16

3.709

M81750: H. sapiens myeloid cell nuclear differentiation antigen mRNA

0.104%

31

3.824

AA121509:zk88c10.s1

p-value

Number present

t-score

Accession: Definition/Description or EST name

0.104%

21

3.023

Z11697: Homo sapiens mRNA for HB15

0.104%

31

3.952

D67031: Homo sapiens ADDL mRNA for adducin-like protein

0.123%

29

3.565

J02923: Human 65-kilodalton phosphoprotein (p65) mRNA

0.123%

21

3.271

L10717: Homo sapiens T cell-specified tyrosine kinase mRNA

0.145%

26

2.955

AL031228:dJ1033B10. 10/Membrane protein with histidine rich charge clusters

0.145%

24

3.512

AB011102: Homo sapiens mRNA for KIAA0530 protein

0.170%

25

2.843

M80482: Human subtilisin-like protein (PACE4) mRNA

0.199%

19

3.215

AF072099: Homo sapiens immunoglobulin-like transcript 3protein variant 1 gene

0.199%

28

3.319

J03037: Human carbonic anhydrase II mRNA

0.199%

31

2.979

D21261: Human mRNA for KIAA0120 gene

0.199%

31

3.542

L06797: HUMGPCR Human (clone L5) orphan G protein-coupled receptor mRNA

B

   
  1. The 20 patients were grouped into early-stage (Stage I and II disease) category and late-stage (Stage III and IV disease) category. A; Similarly, patients without cervical nodal metastasis (N0) were compared to those with nodal disease (N1–N3). B; Genes whose expression in tumor was different in normal mucosa and which were most different between the clinical stage and nodal disease subgroups were identified by statistical regression analysis (t test). The genes identified within the two subgroups are listed. Note that HSAL2 were identified in both subgroups. Only genes that were present in at least 5 samples were included.