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Table 3 Activity of fotemustine in relation to group of dose and histotype

From: Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation

 

Group A, no. pts (%) (histotype)

Group B, no. pts (%) (histotype)

Group C, no. pts (%) (histotype)

Partial Response

2 (40%)

(2 AA)

4 (26.5%)

(1 GBM, 3 AOD)

2 (10%)

(1 AA, 1 AOD)

Stable Disease

2 (40%)

(1 GBM, 1 AA)

4 (26.5%)

(1 GBM, 2 AA, 1 AOD)

5 (25%)

(2 GBM, 1 AA, 2 AOA)

Progression

1 (20%)

(1 GBM)

7 (47%)

(2 GBM, 2 AA, 3 AOA)

13 (65%)

(6 GBM, 2 AA, 2 AOA, 3 AOD)

Total pts

5

15

20

Total GBM

2/5 (40%)

4/15 (26.5%)

8/20 (40%)

  1. AA, anaplastic astrocytoma; AOA, anaplastic oligoastrocytoma, AOD, anaplastic oligodendroglioma; GBM, glioblastoma multiforme; no., number; pts, patients