Figure 1

Scatter plots of the age at diagnoses of breast cancer based on BRCA mutation status and genotypes of each TP53 polymorphism. Panel A contains the age distribution of Arg72pro polymorphism based on BRCA mutation status for homozygous carriers of 72Arg (GG) and 72Pro (CC) genotypes or heterozygous carriers (GC). For the BRCA1 mutation-positive group, the G,G carriers (n = 20) had a mean age ± st. err.(standard error) = 43.9 ± 2.1; the GC carriers (n = 18) had mean age ± st. err. = 44.4 ± 2.3; and the CC carriers (n = 4) had a mean age ± st. err. = 39.5 ± 6.6. For the BRCA2 mutation-positive group, the GG carriers (n = 29) had a mean age ± st. err = 43 ± 1.6; the GC carriers (n = 24) had a mean age ± st. err. = 40.5 ± 1.7; and the CC carrier (n = 4) had a mean age ± st. err. = 53 ± 4.8. For the BRCA mutation-negative group, the GG carriers (n = 31) had a mean age ± st. err. = 48.1 ± 1.5; the GC carriers (n = 25) had a mean age ± st. err. = 46.0 ± 1.5; and the CC carriers (n = 2) had a mean age ± st. err. = 48 ± 11. Panel B contains the age distribution of Ins16 polymorphism based on BRCA mutation status for homozygous carriers Ins16minus [- -] and ins16 [+ +] genotypes or heterozygous carriers [- +]. For the BRCA1 mutation-positive group, the [- -] carriers (n = 26) had a mean age ± st. err. = 41.7 ± 1.9; the [- +] carriers (n = 16) had a mean age ± st. err. = 46.9 ± 2.3; and there were no homozygous [+ +] carriers. For the BRCA2 mutation-positive group, the [- -] carriers (n = 38) had a mean age ± st. err. = 43 ± 1.4; the [- +] carriers (n = 17) had a mean age ± st. err. = 40.5 ± 2.0; and the [+ +] carriers (n = 2) had a mean age ± st. err. = 55 ± 1. For the BRCA mutation-negative group, the [- -] carriers (n = 38) had a mean age ± st. err. = 47.3 ± 1.5; the [- +] carriers (n = 20) had a mean age ± st. err. = 46.9 ± 1.5; and there were no homozygous [+ +] carriers.