Figure 1

Maximum likelihood tree showing the relationship between individual patients' mtgenomes derived from both blood and NAF. There are two independent sequences for each blood sample (MCv2 and CE; red circles), and three independent sequences for each NAF sample (MCv2 sequences from GGI and NIST, and CE sequences; yellow circles). Results are also clustered according to haplogroups. Individual CMG1182 has several identical polymorphisms to haplogroup M and therefore clusters with this group even though she is haplogroup K. Individual CMG1071 was excluded from this analysis because the three NAF sequences had several nucleotide differences. Black circles represent outlier sequences.