Figure 2From: The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis Effect of PSK on PBL proliferation. PBLs were cultured with PSK or IL-2 or with PSK+IL-2. PBLs (50 × 104 cells) were seeded in quadruplicate in 96-well plates. The proliferation was determined by BrdU incorporation and absorbance measurement. PSK showed a synergistic effect with IL-2, increasing PBL proliferation. PSK alone did not induce PBLs proliferation. Each column represents the mean of five independent experiments ± SD. *P < 0.001 versus control.Back to article page