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Table 3 Protein levels which characterized advanced PDAC stage

From: Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis

 

Number of specimens (%)

 

Marker

Low protein level

High protein level

p-value

 

I

II

III

IV

I

II

III

IV

 

Cytoplasm

PTEN

1 (7)

8 (53)

6 (40)

0

1 (9)

0

8 (73)

2 (18)

0.01

βCAT

1 (6)

8 (50)

5 (31)

2 (13)

0

1 (10)

9 (90)

0

0.04

p-NFκB

1 (5)

9 (47)

7 (37)

2(11)

0

0

5 (100)

0

0.05

Nucleus

         

Y705p-STAT3

0

0

6 (75)

2 (25)

1 (6)

9 (50)

8 (44)

0

0.01

p-GSK3β

1 (5)

9 (45)

8 (40)

2 (10)

0

0

6 (100)

0

0.05

  1. Listed are tumors of stage I to IV, and their proportions (%) in low/high protein levels. Advanced PDAC stage (III and IV) associated with high protein levels (PTEN, βCAT, p-NFκB and p-GSK3β) and low p-STAT3 levels (Fisher's exact test, p ≤ 0.05).