Figure 2

Tumor size is reduced after CT-322 treatment in a syngeneic model of pancreatic cancer. Orthotopic murine Pan02 tumors were established in C57BL/6J wild-type mice. Treatment twice weekly i.p. injections of CT-322 (30 mg/kg), gemcitabine (3.5 mg/animal/injection) (GEM), or CT-322 (CT) + GEM was started 7 days after tumor cell injection and continued for 6 weeks, at which point animals were sacrificed. Mean (+/- SEM) tumor weight at the time of sacrifice is displayed. The combination treatment of CT-322 and GEM significantly inhibited tumor growth (control 0.44 ± 0.11 g, 0.153 ± 0.01 g; n = 8/group except CT+GEM n = 10; p < 0.05).