Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

Table 5 Gene name, description, and function of the 14-gene prognostic signature and the overlap with previously reported signatures

Gene	Paik et al	van't Veer et al	Dai et al	Gene Description	Gene Function
BUB1			x	BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)	cell cycle
CCNB1	x			cyclin B1	regulation of cell cycle
CENPA		x	x	centromere protein A, 17kDa	chromosome organization and biogenesis (sensu Eukarya), nucleosome assembly
DC13		x		DC13 protein	assembly of cytochrome oxidase
DIAPH3		x	x	diaphanous homolog 3 (Drosophila)	actin cytoskeleton organization and biogenesis
MELK		x		maternal embryonic leucine zipper kinase	protein amino acid phosphorylation, ATP binding
MYBL2	x			v-myb myeloblastosis viral oncogene homolog (avian)-like 2	anti-apoptosis, regulation of cell cycle, development
ORC6L		x	x	origin recognition complex, subunit 6 homolog-like (yeast)	DNA replication
PKMYT1			x	membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	protein amino acid phosphorylation, regulation of cyclin dependent protein kinase activity
PRR11			x	proline rich 11	E2F transcription factor taget gene, regulation of cell cycle
RACGAP1			x	Rac GTPase activating protein 1	electron transport
RFC4		x		replication factor C (activator 1) 4, 37kDa	DNA replication
TK1			x	thymidine kinase 1, soluble	DNA metabolism
UBE2S			x	ubiquitin-conjugating enzyme E2S	ubiquitin cycle

ISSN: 1471-2407