From: Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance
ll Line | Treatment | Dose 8 | Dose 9 | Dose 10 | Dose 11 | Dose 12 | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Resistance Factor | Relative Uptake | Resistance Factor | Relative Uptake | Resistance Factor | Relative Uptake | Resistance Factor | Relative Uptake | Resistance Factor | Relative Uptake |
MCF-7DOX-2 | Doxorubicin | 1.80 | 93% | 2.48 | 46%* | 3.59 | 37%** | 42.5 | 37%** | 27.8 | 33%*** |
 | Epirubicin | 0.84 | 95% | 2.91 | 38%** | 6.99 | 29%*** | 14.8 | 27%* | 4.79 | 28%** |
MCF-7EPI | Doxorubicin | 1.82 | 108% | 39.2 | 17%*** | 130.8 | 13%*** | 391.6 | 13%*** | 203.4 | 19%*** |
 | Epirubicin | 1.05 | 114% | 93.9 | 11%*** | 422.6 | 9%*** | 486.2 | 9%** | 815.3 | 14%** |
MCF-7TAX-2 | Paclitaxel | 1.00 | 115% | 19.9 | 16%*** | 119.2 | 10%*** | 156.3 | 3%*** | 535.2 | 2%*** |
 | Docetaxel | 0.67 |  | 8.19 |  | 25.4 |  | 37.5 |  | 72.6 |  |
MCF-7TXT | Paclitaxel | 1.35 | 77% | 29.4 | 30%*** | 16.9 | 17%*** | 148 | 28%** | 251 | 9%*** |
 | Docetaxel | 1.05 |  | 15.9 |  | 3.00 |  | 30.8 |  | 79.2 |  |