BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

Table 1 Summary of the molecular and histological features of the colorectal polyps analyzed

	Molecular Classification						Histological classification
Sample	KRAS	BRAF	PIK3CA	CIMP	MLH1 methylation	Microsatellite instability	Polyp type	Dysplasia
1	G12D	-	-	Negative	UnMet	MSS	MHA	Mild
2	G12D	-	-	Negative	nd	MSS	MHA	Mild
3	G12V	-	-	nd	UnMet	MSS	MHA	Mild
4	G12V	-	-	Negative	nd	MSS	HP	-
5	G13D	-	-	Negative	nd	MSS	HP	-
6	G13D	-	-	Negative	nd	MSS	MHA	Mild
7	-	V600E	-	Positive	UnMet	MSS	SA	Mild
8	-	V600E	-	Positive	UnMet	MSS	SA	Mild
9	-	V600E	-	Positive	nd	MSS	SA	Mild
10	-	V600E	-	Negative	nd	MSS	SA	Mild
11	-	V600E	-	nd	nd	MSS	SA	Moderate
12	-	-	R1023Q	nd	nd	MSS	MHA	Mild
13	-	-	-	Negative	UnMet	MSS	MHA	Mild
14	-	-	-	Negative	UnMet	MSS	HP	-
15	-	-	-	Negative	UnMet	MSS	MHA	Mild
16	-	-	-	nd	nd	MSS	MHA	Mild
17	-	-	-	nd	nd	MSS	HP	-

UnMet – unmethylated; nd – not determined; MHA – Mixed hyperplastic and adenomatous; HP – Hyperplastic polyp; SA – Serrated adenoma

ISSN: 1471-2407