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Table 4 Odds ratio and 95% CI for the association between plasma IGFBP-3 or colonic tissue IGFBP-3 and apoptosis

From: Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

 

Apoptosis1

    

Plasma IGFBP-3

Lower Half/Upper Half (n)

Unadjusted OR (95% CI)2

P

Adjusted OR (95% CI)2,3

P

Quartile 4

59/44

1.0 (Reference)

--

1.0 (Reference)

--

Quartile 3

57/44

1.0 (0.6, 0.7)

0.90

1.0 (0.6, 0.7)

0.90

Quartile 2

58/45

1.0 (0.6, 0.7)

0.89

1.0 (0.6, 0.7)

0.89

Quartile 1

58/50

0.9 (0.5, 1.5)

0.60

0.9 (0.5, 1.5)

0.60

P for linear trend

  

0.70

 

0.70

Colonic tissue IGFBP-3

Lower Half/Upper Half (n)

Unadjusted OR (95% CI)2

P

Adjusted OR (95% CI)2,4

P

Quartile 4

63/43

1.0 (Reference)

--

1.0 (Reference)

--

Quartile 3

62/51

0.8 (0.5, 1.4)

0.50

0.6 (0.3, 1.1)

0.12

Quartile 2

64/43

1.0 (0.6, 1.8)

0.96

0.8 (0.5, 1.5)

0.57

Quartile 1

51/70

0.5 (0.3, 0.8)

0.01

0.5 (0.3, 0.8)

0.009

P for linear trend

  

0.10

 

0.04

  1. 1 Number of subjects in each quartile that fall in the lower half or upper of apoptosis
  2. 2 Odds ratio (OR) and 95% confidence interval (CI), odds of being in the lower 50th percentile of apoptosis.
  3. 3 No potential confounders remained in the final model for Plasma IGFBP-3.
  4. 4 Adjusted for red meat for Tissue IGFBP-3.
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BMC Cancer

ISSN: 1471-2407

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