From: Expression of estrogen receptor beta in the breast carcinoma of BRCA1 mutation carriers
Parameter | BRCA1-associated breast cancers n = 48 | Control group n = 120 | P-value |
---|---|---|---|
Age | |||
median (range) | 45 (29 – 68) | 57 (38 – 85) | <0.0001 |
Age > 50 years | 16 (33%) | 82 (68%) | |
Histological type | |||
invasive ductal | 42 (87%) | 103 (85.8%) | 0.7993 |
invasive lobular | 1 (2%) | 10 (8.3%) | 0.14 |
medullary like | 5 (10%) | 0 | < 0.001 |
other | 0 | 9 (7.5%) | < 0.001 |
Tumor grade | |||
I | 1 (2.0%) | 36 (29%) | <0.001 |
II | 11 (22.9%) | 53 (44.1%) | 0.0122 |
III | 27 (56.2%) | 26 (21.7%) | <0.0001 |
unknown | 9 (18.7%) | 5 (4.2%) | 0.0017 |
Tumor size | |||
median | 2.2 | 3.0 | 0.14 |
≤ 2 cm | 28 (58.3%) | 53 (44.1%) | 0.102 |
> 2 cm ≤ 5 cm | 16 (33.3%) | 50 (41.6%) | 0.282 |
> 5 cm | 3 (6.2%) | 17 (14.1%) | 0.147 |
unknown | 1 (2.0%) | 0 | |
Lymph node | |||
negative | 34 (70.8%) | 52 (43.3%) | 0.001 |
positive ≤ 3 | 8 (16.6%) | 38 (31.6%) | 0.015 |
positive >3 | 4 (8.3%) | 22 (18.0%) | 0.104 |
unknown | 2 (4.1%) | 8 (6.6%) | |
Bilateral breast cancer | 13 (27.1%) | 2 (1.7%) | <0.0001 |
Mutation: | |||
5382insC | 37 (77.5%) | ||
C61G | 10 (20.4%) | ||
4153delA | 1 (2%) |