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Table 4 GO and pathway annotation of genes and pathways altered in metastatic prostate cancer

From: Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process

Probe ID

Gene Symbol

Overall FC

FC_P1

FC_P2

FC_P3

FC_P4

Bone remodeling

     

34342_s_at

SPP1

24.7

24.16

26.78

4.75

5.39

2092_s_at

SPP1

11.8

14.05

12.94

3.35

4.07

47958_r_at

ANKH

-2

-2.23

-2.31

-2.03

-3.66

65035_at

TF1P11

-2.31

-2.28

-2.63

-2.97

-3.77

44596_at

TWIST2

-2.45

-2.7

-2.12

-2.94

-2.35

40333_at

BMP4

-2.5

-2.86

-2.89

-3

-5.23

49273_g_at

BMP7

-2.81

-4.58

-4.89

-6.82

-13.13

Cell Adhesion

     

34342_s_at

SPP1

24.7

24.16

26.78

4.75

5.39

2092_s_at

SPP1

11.8

14.05

12.94

3.35

4.07

64719_at

FN1

7.5

27.07

6.02

4.05

4.93

59070_at

HNT

5

5.37

9.69

12.08

13.67

62628_at

PCDHGC3

3.4

2.24

5.44

2.97

2.42

44892_at

MLLT4

3.3

2.63

2.07

6.21

7.48

47064_at

HNT

3.27

2.98

4.37

8.07

8.4

66327_at

PKP4

2.79

3.31

3.88

4.56

6.2

35246_at

TYRO3

2.4

-5.43

-3.58

-6.35

-5.18

659_g_at

THBS2

1.9

2.39

2.37

2.26

2.7

59623_at

PCDH18

-2.22

-2.09

-2.89

-2.17

-2.39

53497_at

ITGB8

-2.38

-2.88

-2.69

-3.51

-13.81

60876_at

COL8A2

-2.38

-2.26

-3.26

-3.61

-2.25

47007_s_at

NINJ2

-2.63

-2.55

-3.4

-3.3

-5.93

103_at

THBS4

-2.7

-2.02

-3.37

-2.16

-3.26

46520_at

ROBO2

-2.86

-2.58

-4.96

-4.14

-4.46

45939_at

CNTN3

-3.33

-3.38

-2.14

-7.41

-11.94

47535_at

CDH10

-3.7

-4.87

-3.19

-8.27

-4.65

56192_at

PCDH7

-3.7

-2.5

-5.33

-5.74

-3

52999_at

BOC

-4.17

-2.42

-8.8

-12.25

-6.16

43930_at

LSAMP

-4.35

-3.05

-7.62

-9.76

-7.67

33883_at

EFS

-4.76

-5.43

-3.58

-6.35

-5.18

64342_at

CTGF

-5.26

-4.21

-4.15

-20.44

-14.87

64423_s_at

BOC

-6.67

-3.63

-8.16

-11.8

-54.66

52652_g_at

COL8A2

-10

-7.95

-9.99

-11.56

-9.75

51214_at

PKP1

-14.29

-11.57

-16.34

-11.83

-17.85

52140_at

PGM5

-25

-23.87

-26.5

-44.27

-17.72

Cell_cycle

     

47231_at

DLG1

3.57

3.4

4.77

6.22

5.7

45574_g_at

TPX2

3.49

11.09

2.57

3.24

8.6

54219_at

7-Sep

3.23

3.3

2.79

2.17

3.27

53998_at

CLASP2

3.09

2.67

2.84

4.18

4.13

37933_at

RBBP6

3.08

2.27

5.42

7.52

8.79

53568_at

7-Sep

2.97

3.94

2.4

3.53

2.49

51815_at

TERF1

2.54

2.11

4.78

5.1

3.51

1797_at

CDKN2D

2.41

3.65

2.76

2.46

2.47

50084_at

DNCH1

2.29

2.42

2.15

2.11

2.29

66955_at

EML4

2.13

2.22

3.3

6.8

5.09

1833_at

CDK2

2.12

3.14

2.56

2.05

2.45

52744_at

HRPT2

2.07

2.73

2.62

3.4

3.36

60568_at

BCL2

2.07

2.18

3.27

3.35

3.75

41632_at

E2F3

2.05

2.34

2.04

2.2

2.15

59821_at

BCL2

1.87

2.89

3.13

3.58

3.86

36101_s_at

VEGF

1.53

2.5

2.38

2.53

3.06

63158_at

GRLF1

1.27

3.55

2.63

2.3

3.45

65908_at

CHES1

-2.1

-3.3

-2.11

-2.34

-5.51

46664_at

PYCARD

-2.14

-2.36

-2.06

-2.94

-2.08

48980_at

ZAK

-2.25

-2.02

-4.8

-2.06

-2.07

36838_at

KLK10

-2.38

-3.38

-2.94

-2.07

-6.13

50199_s_at

RGC32

-2.73

-2.49

-3.64

-5.45

-4.17

39780_at

PPP3CB

-2.74

-3.82

-2.36

-3.06

-2.85

33864_at

ZMYND11

-2.78

-4.77

-2.85

-3.79

-3.79

49504_r_at

MCC

-3.45

-5.9

-5.71

-5.08

-5.84

37005_at

NBL1

-3.83

-3.34

-4.27

-4.31

-6.36

234_s_at

PTN

-3.86

-2.92

-5.02

-2.15

-3.33

37283_at

MN1

-4.63

-4.47

-7.36

-5.55

-7.48

45217_at

PDGFC

-4.82

-4.32

-7.53

-8.81

-3.97

1005_at

DUSP1

-6.16

-6.53

-16.66

-3.02

-3.19

36669_at

FOSB

-7.85

-8.81

-6.27

-7.6

-8.39

34820_at

PTN

-12.55

-11.62

-31.95

-10.24

-27.11

37430_at

ALOX15B

-21

-12.47

-12.41

-14.17

-9.1

Transcription

     

1577_at

AR

10

14.35

12.97

12.24

14.78

65001_r_at

TBL1XR1

7

3.53

12.3

4.06

7.19

1578_g_at

AR

6.18

7.56

4.86

5.32

6.37

42733_i_at

FOXP1

5.6

2.61

5.92

14.54

14.09

52769_at

POLR2A

5.1

2.93

4.04

12.61

11.14

54342_at

ZNF605

4.55

2.75

6.89

4.85

4.04

65083_at

RNPC2

4.1

3.18

3.96

6.01

9.19

42734_r_at

FOXP1

3.5

2.01

4.49

7.53

8.6

48423_at

ZNF621

3.4

2.11

8.51

3.74

7.33

51543_at

ZNF395

3.32

2.99

5.52

6.73

6.51

44546_at

ZNF148

3

3.32

2.59

4.72

4.18

49633_at

HES6

3

5.76

2.26

2.34

6.72

51842_at

CBX4

3

3.32

2.61

5.21

3.08

54981_r_at

SFPQ

3

2.27

4.87

4.9

5.33

60076_at

SOX4

3

3.32

3.77

2.09

2.72

43580_at

MORF4L2

2.93

2.42

3.49

3.38

6.52

34715_at

FOXM1

2.84

6.82

2.17

2.9

2.99

40674_s_at

HOXC6

2.81

3.09

2.48

6.67

4.56

56981_at

ZKSCAN1

2.77

2.65

2.4

2.6

4.04

55293_at

ADNP

2.73

2.44

3.6

3.98

3.9

43545_at

ZNF281

2.7

2.17

3.21

3.05

4.19

32653_at

BRD8

2.56

2.11

3.73

3.22

4.45

53846_at

FLJ21616

2.55

3.1

2.96

5.41

5.92

45953_at

NCOA1

2.42

6.53

4.13

3.58

6.06

46006_at

ERCC8

2.35

2.35

2.7

3.36

5.84

50911_at

RLF

2.35

2.18

2.38

4.07

4.92

58641_at

MAML3

2.33

2.86

2.31

5.61

5.44

42571_at

MORF4L2

2.32

2.21

3.7

3.99

3.48

43120_at

MLL3

2.32

2.55

2.48

2.14

2.74

31437_r_at

ESR2

2.3

2.06

3.06

3.13

4.09

50532_at

JARID1A

2.3

3.22

3.32

3.54

4.12

44939_at

MLL3

2.22

2.55

2.48

2.14

2.74

55502_at

FOXO3A

2.21

2.44

3.6

3.98

3.9

52328_at

SP3

2.2

2.13

2.62

3.38

3.11

54220_r_at

NLK

2.16

2.39

4.23

3.94

4.41

41632_at

E2F3

2.04

2.34

2.04

2.2

2.15

66313_at

HIPK1

2

2.09

2.85

2.95

3.98

42193_r_at

---

1.9

2.16

2.04

2.66

3.29

39540_at

ZBTB7A

1.89

2.42

3.27

3.03

2.61

63158_at

GRLF1

1.79

3.55

2.63

2.3

3.45

65908_at

CHES1

-2.13

-3.3

-2.11

-2.34

-5.51

36770_at

STAT2

-2.17

-2.3

-3.47

-2.82

-3.75

64963_at

EYA4

-2.17

-3.06

-3.31

-2.55

-5.01

65945_at

PNRC2

-2.17

-2.08

-2.26

-2.61

-2.24

1454_at

SMAD3

-2.27

-2.17

-2.51

-2.02

-2.07

54658_at

PSPC1

-2.33

-3.18

-2.22

-3.63

-13.16

44596_at

TWIST2

-2.5

-2.7

-2.12

-2.94

-2.35

46704_at

KLF3

-2.63

-2.38

-2.29

-2.19

-3.33

51253_at

ZBTB4

-2.63

-2.92

-3.18

-2.63

-3.93

287_at

ATF3

-2.78

-2.11

-2.33

-2.63

-3.3

33864_at

ZMYND11

-2.78

-4.77

-2.85

-3.79

-3.79

63526_f_at

KLF6

-2.78

-3.21

-2.48

-2.71

-3.33

64932_at

VPS36

-2.86

-4.56

-2.88

-2.48

-2.27

45680_at

ZNF537

-2.94

-2.77

-3.37

-2.78

-3.74

43431_at

SOX2

-3.03

-2.09

-3.8

-7.43

-7.34

47620_at

XAB2

-3.33

-2.7

-8.25

-7.6

-8.49

465_at

HTATIP

-3.45

-2.52

-2.37

-4.49

-2.47

37863_at

EGR2

-4.55

-7.7

-5.52

-7.23

-15.41

48587_at

KLF4

-4.76

-3.77

-3.62

-4.57

-12.5

36634_at

BTG2

-5.26

-6.99

-3.13

-9.25

-5.22

279_at

NR4A1

-6.25

-5.31

-8.04

-5.11

-8.48

280_g_at

NR4A1

-7.14

-8.68

-13.49

-5.82

-8.58

40375_at

EGR3

-8.33

-9.89

-7.71

-8.49

-6.44

53766_at

PER3

-9.09

-15.43

-6.79

-5.56

-6.29

MAP Kinase Pathway

     

1562_g_at

DUSP8

5.8

2.42

5.01

16.6

5.86

1104_s_at

HSPA1A/HSPA1B

4.1

7.81

2.77

2.81

5.02

51474_at

MAP4K4

3.57

4.86

4.32

8.7

8.52

60658_at

---

3.5

-3

-2.96

-3.6

-3.73

50375_at

SOS1

3

2.97

4.08

4.57

3.79

33855_at

GRB2

2.55

2.29

2.61

3.85

2.1

42838_f_at

MAP3K8

2.3

2.25

3.4

2.78

2.08

54220_r_at

NLK

2.16

2.39

4.23

3.94

4.41

790_at

NGFB

1.86

2.08

2.35

3.37

2.9

48980_at

ZAK

-2.27

-2.02

-4.8

-2.06

-2.07

43053_g_at

PAK1

-2.7

-6.31

-2.46

-2.83

-2.11

39780_at

PPP3CB

-2.78

-3.82

-2.36

-3.06

-2.85

468_at

FGF13

-2.78

-4.35

-4.35

-2.11

-2.56

65904_at

---

-2.94

-2.05

-3.48

-4.18

-3.43

1292_at

DUSP2

-3.13

-3.72

-3.66

-3.17

-2.19

57299_s_at

RRAS

-3.23

-3

-2.96

-3.6

-3.73

1970_s_at

FGFR2

-5.56

-2.55

-13.13

-8.88

-4.92

1005_at

DUSP1

-6.25

-6.53

-16.66

-3.02

-3.19

279_at

NR4A1

-6.25

-5.31

-8.04

-5.11

-8.48

280_g_at

NR4A1

-7.14

-8.68

-13.49

-5.82

-8.58

1916_s_at

FOS

-7.69

-7.58

-21.81

-6.93

-11.58

1915_s_at

FOS

-9.09

-7.59

-26.38

-11.03

-12.11

2094_s_at

FOS

-16.67

-10.72

-25.75

-13.72

-16.45

  1. Genes whose median value shows at least 2 fold change in every metastatic patient were annotated by NIH's DAVID tool. Genes belonging to selected GO categories with a significant number of differentially expressed genes are shown. Overall_FC, the fold change in the mean expression value of all metastatic samples compared to the primary samples;FC_P1, FC_P2, FC_P3, FC_P4; a patient-specific median expression value was calculated using all the samples from each patient. This was compared to the median value for the primary tumors. Patient P4 had only sample and this was considered the median.
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