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Table 4 Genes differentially expressed in lobular versus ductal invasive carcinomas by rank products and/or pairwise analysis

From: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis

Probe Set1

Gene Symbol

Gene Title

Rank products

Pairwise comparison

   

Fold-change

Incr/Decr

Cell adhesion

201131_s_at

CDH1↓

Cadherin 1, type 1, E-cadherin (epithelial)

-6.0

3/19

207169_x_a

DDR1↓

Discoidin domain receptor family, member 1

n

5/19

204776_at

THBS4↑

Thrombospondin 4

n

19/2

219087_at

ASPN↑

Asporin (LRR class 1)

3.9

23/0

Wnt signalling

223168_at

RHOU↓

RAS homolog gene family, member U

n

2/20

203230_at

DVL1↑

Dishevelled, dsh homolog 1 (Drosophila)

n

20/0

Protein ubiquitination

215392_at

USP3↓

Ubiquitin specific peptidase 3

-5.0

1/21

218247_s_at

RKHD2↓

Ring finger and KH domain containing 2

-4.6

0/19

1569472_s_at

TTC3↓

Tetratricopeptide repeat domain 3

-4.5

0/23

Regulation of transcription

226115_at

AHCTF1↓

AT hook containing transcription factor 1

-4.0

0/22

201587_s_at

IRAK1↓

Interleukin-1 receptor-associated kinase 1

n

2/19

202599_s_at

NRIP1↓

Nuclear receptor interacting protein 1

n

0/19

201773_at

ADNP↓

Activity-dependent neuroprotector

n

0/20

203637_s_at

MID1↑

Midline 1 (Opitz/BBB syndrome)

4.0

20/0

235444_at

FOXP1↑

Forkhead box P1

n

19/4

Electron and protein transport

204351_at

S100P↓

S100 calcium binding protein P

-5.3

0/19

225177_at

RAB11FIP1↓

RAB11 family interacting protein 1 (class I)

-3.5

2/21

204041_at

MAOB↑

Monoamine oxidase B

3.5

20/4

212902_at

SEC24A↑

SEC24 related gene family, member A

3.5

19/2

Cell cycle regulation, cell proliferation and signaling

204170_s_at

CKS2↓

CDC28 protein kinase regulatory subunit 2

-4.8

2/20

207414_s_at

PCSK6↓

Proprotein convertase subtilisin/kexin type 6

n

4/19

209678_s_at

PRKCI↓

Protein kinase C, iota

n

0/22

209817_at

PPP3CB↓

Protein phosphatase 3, catalytic subunit, beta isoform (calcineurin A beta)

n

0/24

201324_at

EMP1↑

Epithelial membrane protein 1

n

21/0

Metabolism and enzyme activity

205509_at

CPB1↓

Carboxypeptidase B1 (tissue)

-11.1

0/19

223746_at

STK4↓

Serine/threonine kinase 4

-4.5

2/20

225491_at

SLC1A2↓

Solute carrier family 1 (glial high affinity glutamate transporter), member 2

-4.1

0/20

211379_x_at

B3GALT3↓

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3

-4.0

0/20

219073_s_at

OSBPL10↓

Oxysterol binding protein-like 10

-4.0

1/21

229366_at

CRBN↓

Cereblon

-3.6

0/20

226350_at

CHML↓

Choroideremia-like (Rab escort protein 2)

n

0/24

217717_s_at

YWHAB↓

Tyrosine 3-monooxygenase/tryptophan 5-mono-oxygenase activation protein, beta polypeptide

n

1/20

49452_at

ACACB↑

Acetyl-Coenzyme A carboxylase beta

n

19/0

220770_s_at

LOC63920↑

Transposon-derived Buster3 transposase-like

5.3

24/0

Actin and cytoskeletal protein binding

211776_s_at

EPB41L3↓

Erythrocyte membrane protein band 4.1-like 3

-5.3

0/21

201341_at

ENC1↓

Ectodermal-neural cortex (with BTB-like domain)

n

19/3

Nuclear components

218585_s_at

DTL↓

Denticleless homolog (Drosophila)

-4.6

1/19

225706_at

GLCCI1↓

Glucocorticoid induced transcript 1

-4.5

0/25

241863_x_at

TTC14↓

Tetratricopeptide repeat domain 14

-4.4

1/20

228069_at

FAM54A↓

Family with sequence similarity 54, member A

-3.8

0/20

208576_s_at

HIST1H3B↓

Histone 1, H3b

-3.3

1/19

Other

1568838_at

--- ↓

Full-length cDNA clone CS0DF033YE17 of Fetal brain of Homo sapiens (human)

-5.0

1/20

226067_at

C20orf114↓

Chromosome 20 open reading frame 114

-4.9

0/19

1553979_at

--- ↓

Homo sapiens, clone IMAGE:3906992, mRNA

-4.1

0/19

230534_at

MGC15634↓

Hypothetical protein MGC15634

-3.6

2/20

226671_at

--- ↓

CDNA clone IMAGE:4797120

-3.8

2/20

219768_at

VTCN1↑

V-set domain containing T cell activation inhibitor 1

7.8

21/2

214657_s_at

TncRNA↑

Trophoblast-derived noncoding RNA

4.5

21/0

213004_at

ANGPTL2↑

Angiopoietin-like 2

n

19/4

  1. ↑ – upregulated in lobular carcinoma; ↓ – downregulated in lobular carcinoma; n – gene not found by rank products at the level of 10% of false positives, Incr/decr – increase or decrease in lobular versus ductal carcinoma by pairwise comparison.
  2. 1All 32 probe sets identified by combined pairwise comparison and rank products are included, also a number of genes found by pairwise comparison were validated by immunohistochemistry (DVL1, DDR1, EMP1), therefore, functional categories also include named genes identified by pairwise analysis.