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Table 3 Molecular signatures specifying breast cancer subgroups as defined by hierarchical clustering and Chi2 analysis.

From: A new molecular breast cancer subclass defined from a large scale real-time quantitative RT-PCR study

SG1

SG2

SG3

SG5

SG6

SG7

SG9

SG10

SG12

ACADM

ERRA

BCL2

MTA3

ESR2

ABCC5

BCL2

ABCG2

AKT2

BMI1

IGF1

CCND1

SPP1

IGF1

AKT2

ERBB2

BMI1

CDKN1B

ERRG

NCOA3

CDK4

 

KRT19

AREG

GRB7

CDKN1B

E4F1

MYC

PTGS2

E4F1

 

MYBL2

EZH2

IRS1

EPHA2

EZH2

RXRA

 

ESR1

  

HDAC6

NCOA3

ERBB2

HDAC6

  

GATA3

  

PRKAR1A

PGC1A

ERBB4

MAD2L1

  

GSTP1

   

SPP1

ESR1

PR

  

KRT19

    

GATA3

PRKAR1A

  

LIV1

    

GSTP1

PTEN

  

MAD2L1

    

IGF1R

RXRA

  

MTA3

    

IGFBP4

 
  

PGC1A

    

LIV1

 
  

SERPINB5

    

PR

 
  

TSK/E2IG4

    

MYBL2

 
  

ZNF217

    

MYC

 
       

SERPINB5

 
       

TFF1/pS2

 
  1. These signatures included up-regulated (bold characters) or down-regulated genes as indicated. No specific signature was found concerning subgroups 4, 8 and 11, except that a high proportion of tumours from group 4 exhibited the subgroup 3-signature (see Table 4).
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BMC Cancer

ISSN: 1471-2407

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