UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

Table 1 Description of the population

	Controls		Cirrhosis		HCC		HCC vs Controls		HCC vs Cirrhosis
	N	%	N	%	N	%	OR	95%CI	OR	95%CI
Age
< 50	11	7.7%	22	16.4%	17	10.3%	1.0	Ref	1.0	Ref
50–60	39	27.5%	63	47.0%	46	27.9%	0.8	0.3–1.9	1.0	0.5–2.1
60–70	56	39.4%	32	23.9%	61	37.0%	0.7	0.3–1.6	2.9	1.3–6.3
> 70	36	25.4%	17	12.7%	41	24.8%	0.7	0.3–1.8	3.8	1.6–9.3
	142		134		165
m ± sd	62 ± 8.5		58 ± 8.6		62 ± 8.9
Hospital
K.-Bicêtre	53	37.3%	45	33.6%	48	29.1%
Bondy	48	34.0%	53	39.1%	60	36.4%	-	-	-	-
Nancy	13	9.0%	16	12.0%	25	15.1%	-	-	-	-
Beaujon	28	20.0%	20	15.0%	32	19.4%	-	-	-	-
	142		134		165
Social class
White-collar worker	79	56.0%	49	38.0%	82	50.0%	1.0	Ref	1.0	Ref
Blue-collar worker	63	44.0%	80	62.0%	82	50.0%	1.3	0.8–2.0	0.6	0.3–0.9
	142		129		164
Time since cirrhosis diagnosis
0–1 yr			53	43.4%	65	47.8%	-	-	1.0	Ref
> 1–< 5			43	35.2%	42	30.9%	-	-	0.8	0.4–1.5
> 5			26	21.3%	29	21.3%	-	-	0.8	0.4–1.5
			122		136
Cirrhosis characteristics
Heavy drinkers-virus(-)			106	79.1%	102	61.8%
Virus(+) not heavy drinkers			10¹	7.5%	23²	13.9%
Heavy drinkers-virus(+)			10³	7.5%	17⁴	10.3%
Hemochromatosis			1	0.7%	6	3.6%
other or unknown			7	5.2%	17	10.3%
					165

1: 6 anti-HCV (+) 3 HbsAg (+) 1 both; 2: 20 anti-HCV (+) 2 HbsAg (+) 1 both ; 3:9 anti-HCV (+) 1 HbsAg (+); 4:15 anti-HCV (+) 2 HbsAg (+);

ISSN: 1471-2407