From: Prognostic value of histopathology and trends in cervical cancer: a SEER population study
Variable | Hazard ratio(3) (95% confidence interval) | P |
---|---|---|
Demographic characteristics | Â | Â |
SEER area | Â | Â |
   Central registries | 0.95 (0.89–1.01) | 0.099 |
   Western registries | 0.97 (0.91–1.03) | 0.308 |
Age at diagnosis | 1.01 (1.00–1.01) | <0.001 |
Year of diagnosis | 1.00 (1.00–1.01) | 0.013 |
African-American ethnicity (1) | 1.14 (1.07–1.22) | <0.001 |
Marital status (married) (1) | 0.99 (0.94–1.04) | 0.638 |
Pathology | Â | Â |
Histological type (2) | Â | <0.001 |
   SCC microinvasive | 0.28 (0.20–0.39) | <0.001 |
   Carcinoma not otherwise specified | 0.91 (0.79–1.04) | 0.168 |
   Adenocarcinoma excl. mucinous | 1.06 (0.98–1.15) | 0.126 |
   Adenosquamous carcinoma | 1.35 (1.20–1.51) | <0.001 |
   Mucinous | 1.52 (1.23–1.88) | <0.001 |
   Small cell | 1.94 (1.58–2.39) | <0.001 |
Histological High grade (1) | 2.17 (1.93–2.44) | <0.001 |
Localized stage (1) | 0.07 (0.05–0.08) | <0.001 |
Treatments and interactions | Â | Â |
Hysterectomy (1) | 0.26 (0.21–0.31) | <0.001 |
Radiotherapy (1) | 1.01 (0.92–1.11) | 0.810 |
Hysterectomy * Radiotherapy | 2.05 (1.67–2.52) | <0.001 |
High grade * Radiotherapy | 0.60 (0.53–0.69) | <0.001 |
Localized stage * Hysterectomy | 2.87 (2.17–3.78) | <0.001 |
Localized stage * Radiotherapy | 5.24 (4.36–6.29) | <0.001 |
Localized stage * Hysterectomy * Radiotherapy | 0.40 (0.28–0.56) | <0.001 |