tumour | TAMs |  | TGF-β1 |  | TGF-β-R1 |  | TGF-β-R2 |  | Smad3 |  | Smad4 |  | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | low (0–1) | high (2–3) | p value | low (0–1) | high (2–3) | p value | low (0–1) | high (2–3) | p value | neg. | pos. | p value | neg. | pos. | p value | neg. | pos. | p value |
low-grade | 248 | 7 | <0.001 | 165 | 90 | 0.009 | 239 | 16 | 0.148 | 245 | 10 | 0.278 | 111 | 146 | 0.907 | 39 | 214 | 0.295 |
high-grade | 39 | 13 | Â | 44 | 9 | Â | 47 | 7 | Â | 50 | 4 | Â | 22 | 30 | Â | 5 | 47 | Â |
N0 | 167 | 9 | 0.019 | 113 | 63 | 0.202 | 163 | 14 | 0.581 | 167 | 10 | 0.630 | 79 | 99 | 0.579 | 35 | 139 | 0.004 |
N+ | 120 | 11 | Â | 96 | 36 | Â | 123 | 9 | Â | 128 | 4 | Â | 54 | 77 | Â | 9 | 122 | Â |
5 ycrs | 87.0 | 80.0 | 0.261 | 85.6 | 88.8 | 0.459 | 86.4 | 87.0 | 0.787 | 87.0 | 78.6 | 0.631 | 86.1 | 86.6 | 0.991 | 92.5 | 85.4 | 0.896 |
5 ydm | 19.4 | 30.0 | 0.241 | 18.7 | 22.6 | 0.463 | 19.9 | 17.4 | 0.851 | 19.9 | 21.4 | 0.701 | 19.5 | 19.9 | 0.795 | 17.3 | 20.7 | 0.419 |
stroma | TAMs |  | TGF-β1 |  | TGF-β-R1 |  | TGF-β-R2 |  | Smad3 |  | Smad4 |  | ||||||
n | low (0–1) | high (2–3) | p value | low (0–1) | high (2–3) | p value | low (0–1) | high (2–3) | p value | neg. | pos. | p value | neg. | pos. | p value | neg. | pos. | p value |
low-grade | 152 | 104 | 0.134 | 256 | 0 | n.a. | 162 | 94 | 1.000 | 98 | 158 | 0.229 | 140 | 117 | 0.653 | 7 | 249 | 1.000 |
high-grade | 26 | 28 | Â | 52 | 0 | Â | 34 | 20 | Â | 25 | 28 | Â | 27 | 26 | Â | 1 | 52 | Â |
N0 | 59 | 39 | 0.141 | 176 | 0 | n.a. | 102 | 76 | 0.033 | 56 | 121 | 0.001 | 98 | 80 | 0.627 | 5 | 172 | 1.000 |
N+ | 119 | 93 | Â | 132 | 0 | Â | 94 | 38 | Â | 67 | 65 | Â | 69 | 63 | Â | 3 | 129 | Â |
5 ycrs | 84.1 | 87.8 | 0.897 | 86.4 | n.a. | n.a. | 84.7 | 89.5 | 0.245 | 82.3 | 89.3 | 0.003 | 87.5 | 85.4 | 0.753 | 83.3 | 86.5 | 0.812 |
5 ydm | 12.6 | 20.0 | 0.643 | 20.7 | n.a. | n.a. | 24.5 | 12.3 | 0.072 | 25.4 | 16.6 | 0.087 | 21.0 | 18.9 | 0.392 | 14.3 | 20.2 | 0.582 |